Department of Organic Chemistry, Faculty of Chemistry, University of Belgrade, Serbia.
Nat Prod Res. 2012;26(17):1634-7. doi: 10.1080/14786419.2011.585989. Epub 2011 Oct 10.
As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 µg) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.
作为我们正在进行的从海洋和陆地低等生物中寻找新的乙酰胆碱酯酶抑制剂项目的一部分，对来自波斯尼亚和黑塞哥维那的一种叶状地衣，肺衣（Lobaria pulmonaria（L.）Hoffm.）（Lobariaceae）进行了植物化学研究。该研究导致分离出一种乙酰化的去甲二萜混合物，该混合物在薄层色谱板上的乙酰胆碱酯酶抑制试验中表现出中等活性（0.5μg）。我们的研究结果首次表明，地衣物种中高度特异性的代谢物去甲二萜在地衣物种中具有重要意义，它们是寻找这些抑制剂的关键，这些抑制剂仍然是目前治疗阿尔茨海默病的最佳药物。
