可切除胰腺恶性肿瘤患者的内镜超声分期及引导下细针穿刺活检：单中心前瞻性经验

Endoscopic ultrasound staging and guided fine needle aspiration biopsy in patients with resectable pancreatic malignancies: a single-center prospective experience.

作者信息

Karoumpalis Ioannis, Sigalas Panagiotis, Salla Charitini, Diakatou Evanthia, Balatsos Vasileios, Zografos George, Delis Vasileios

机构信息

Department of Gastroenterology, Hepatology and Gastrointestinal Endoscopy Unit, General Hospital of Athens, Greece.

出版信息

Onkologie. 2011;34(10):533-7. doi: 10.1159/000332143. Epub 2011 Sep 19.

DOI:10.1159/000332143

PMID:21985852

Abstract

BACKGROUND

Endoscopic ultrasound staging and guided fine needle aspiration biopsy (EUS-FNA) is a highly accurate diagnostic method, useful in characterizing pancreatic lesions, obtaining definitive tissue diagnosis in patients with suspected pancreatic lesions, and providing accurate locoregional staging that enhances diagnostic certainty and evaluation of appropriateness of surgical intervention. The aims of this study were to evaluate the preoperative contribution of EUS staging and EUS-FNA in patients with suspected resectable pancreatic malignancies.

PATIENTS AND METHODS

A prospective study was conducted in a tertiary referral center. During a 54-month period, a total of 103 consecutive patients were prospectively evaluated with EUS and EUS-FNA. Enrolled in the study were patients with resectable pancreatic lesions, who underwent surgery.

RESULTS

The overall operating characteristics of EUSFNA were sensitivity 96.7%, specificity 90.0%, positive predictive value 98.9%, negative predictive value 75.0%, and diagnostic accuracy 96.1%.

CONCLUSION

EUS and EUS-FNA have a high accuracy and positive predictive value in the preoperative determination of resectability in pancreatic cancer.

摘要

背景

内镜超声分期及引导下细针穿刺活检（EUS-FNA）是一种高度准确的诊断方法，有助于对胰腺病变进行特征性描述，为疑似胰腺病变患者获取明确的组织诊断，并提供准确的局部区域分期，从而提高诊断的确定性以及评估手术干预的适宜性。本研究的目的是评估EUS分期和EUS-FNA对疑似可切除胰腺恶性肿瘤患者的术前诊断价值。