Durgun Yetim T, Basoglu A, Taslak Sengul A, Yetim I, Serdar Bekdemir O, Hokelek M
Department of Thoracic Surgery, Mustafa Kemal University School of Medicine, Antioch, Turkey.
J Int Med Res. 2011;39(4):1230-8. doi: 10.1177/147323001103900411.
Secondary hydatidosis is an important problem encountered during the surgical treatment of hydatid cysts. This study describes an experimental model of secondary hydatidosis by cyst inoculation, used to explore whether simultaneous inoculation of protoscolocidal agents could prevent secondary hydatidosis. Fertile cyst fluid was injected into the pleural space of rabbits alone (group 1, n = 8), and in combination with 2% albendazole solution (group 2, n = 8), 20% hypertonic saline (group 3, n = 8) or 10% povidone-iodine (group 4, n = 8). Computed tomography imaging of the thorax, indirect haemagglutination (IHA) titres and eosinophil counts were used to determine cyst development. After 16 months, three control rabbits had pneumothorax, seven had cysts and four had parenchymal nodules. Histopathological investigation of nodules revealed 87.5% cyst formation. Pleural thickening was observed in rabbits from all groups. Cyst formation rates, IHA titres and eosinophilia counts were higher in group 1 than in groups 2-4. This study demonstrated the experimental formation of secondary hydatidosis and found that topical protoscolocidal agents were beneficial in preventing cyst recurrence.
继发性包虫病是在包虫囊肿外科治疗过程中遇到的一个重要问题。本研究描述了一种通过囊肿接种建立的继发性包虫病实验模型，用于探讨同时接种原头蚴杀灭剂是否能预防继发性包虫病。将有活性的囊液单独注入兔的胸腔（第1组，n = 8），并分别与2%阿苯达唑溶液（第2组，n = 8）、20%高渗盐水（第3组，n = 8）或10%聚维酮碘（第4组，n = 8）联合注入。采用胸部计算机断层扫描成像、间接血凝（IHA）滴度和嗜酸性粒细胞计数来确定囊肿的发展情况。16个月后，3只对照兔出现气胸，7只出现囊肿，4只出现实质结节。结节的组织病理学检查显示87.5%为囊肿形成。所有组的兔均观察到胸膜增厚。第1组的囊肿形成率、IHA滴度和嗜酸性粒细胞增多计数高于第2 - 4组。本研究证实了继发性包虫病的实验性形成，并发现局部应用原头蚴杀灭剂有助于预防囊肿复发。
