Tang H, Zhao J, Hao C
Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
J Int Med Res. 2011;39(4):1438-47. doi: 10.1177/147323001103900432.
This 12-month retrospective study compared pain relief, quality of life (QoL), treatment cost-effectiveness and complication rates in patients with acute osteoporotic vertebral compression fracture (OVCF) undergoing percutaneous vertebroplasty (PVP; n = 58), percutaneous kyphoplasty (PKP; n = 55), or conservative medical therapy (CMT; n = 55). After surgery, Cobb angle and vertebral height were significantly improved in the PKP group. PVP and PKP patients had significantly less pain immediately after surgery than CMT patients, but this difference disappeared between weeks 2-8, only to return from months 6-12. QoL was significantly better among the surgical groups after surgery and was lower in the CMT group than in the surgical groups. Treatment times were shorter with PVP and PKP, but costs were lower with CMT. The rate of secondary fractures during follow-up was greater with CMT. Overall, PVP was considered the first choice treatment for OVCF with refractory pain.
这项为期12个月的回顾性研究比较了接受经皮椎体成形术（PVP；n = 58）、经皮后凸成形术（PKP；n = 55）或保守药物治疗（CMT；n = 55）的急性骨质疏松性椎体压缩骨折（OVCF）患者的疼痛缓解情况、生活质量（QoL）、治疗成本效益和并发症发生率。术后，PKP组的Cobb角和椎体高度显著改善。PVP和PKP患者术后即刻疼痛明显少于CMT患者，但这种差异在术后2 - 8周消失，仅在6 - 12个月时再次出现。术后手术组的生活质量明显更好，CMT组的生活质量低于手术组。PVP和PKP的治疗时间较短，但CMT的成本较低。随访期间CMT组的二次骨折发生率更高。总体而言，PVP被认为是治疗伴有难治性疼痛的OVCF的首选治疗方法。
