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吡嗪酰胺致过敏反应：皮试诊断及成功脱敏。

Pyrazinamide-induced anaphylaxis: diagnosed by skin test and successful desensitization.

机构信息

Division of Immunology and Allergy, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey.

出版信息

Int Arch Allergy Immunol. 2012;157(2):209-12. doi: 10.1159/000327537. Epub 2011 Oct 7.

DOI:10.1159/000327537
PMID:21986254
Abstract

Pyrazinamide (PZA), an antituberculosis drug, may cause hypersensitivity reactions. Here, we report a case of anaphylaxis secondary to a PZA administration for tuberculosis pleuritis. To the best of our knowledge, this is the first reported case of strongly possible IgE-mediated, PZA-induced anaphylaxis proved by skin prick test and oral provocation/desensitization.

摘要

吡嗪酰胺（PZA）是一种抗结核药物，可能引起过敏反应。在此，我们报告了一例因结核性胸膜炎使用 PZA 治疗引起的过敏反应病例。据我们所知，这是首例经皮点刺试验和口服激发/脱敏试验证实的、极可能由 IgE 介导的 PZA 诱导的过敏反应病例。

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