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本文引用的文献

1
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.子宫内膜癌中 PIK3R1 和 PIK3R2 突变的高频揭示了一种调节 PTEN 蛋白稳定性的新机制。
Cancer Discov. 2011 Jul;1(2):170-85. doi: 10.1158/2159-8290.CD-11-0039. Epub 2011 Jun 7.
2
NFAT promotes carcinoma invasive migration through glypican-6.NFAT 通过磷脂聚糖-6 促进癌侵袭迁移。
Biochem J. 2011 Nov 15;440(1):157-66. doi: 10.1042/BJ20110530.
3
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.鉴定 PHLLP1 为肿瘤抑制因子揭示了反馈激活在 PTEN 突变型前列腺癌进展中的作用。
Cancer Cell. 2011 Aug 16;20(2):173-86. doi: 10.1016/j.ccr.2011.07.013.
4
Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2).Ankrd2/ARPP 是一种新型 Akt2 特异性底物,在细胞暴露于 H₂O₂时调节成肌分化。
Mol Biol Cell. 2011 Aug 15;22(16):2946-56. doi: 10.1091/mbc.E10-11-0928. Epub 2011 Jul 7.
5
mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif.mTOR 复合物 2 通过在疏水基序处磷酸化靶向 Akt 进行蛋白酶体降解。
J Biol Chem. 2011 Apr 22;286(16):14190-8. doi: 10.1074/jbc.M111.219923. Epub 2011 Feb 14.
6
Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer.针对乳腺癌中的磷酸肌醇-3(PI3)激酶途径。
Oncologist. 2011;16 Suppl 1:12-9. doi: 10.1634/theoncologist.2011-S1-12.
7
PTEN level in tumor suppression: how much is too little?抑癌基因 PTEN 的失活:过少会带来何种影响?
Cancer Res. 2011 Feb 1;71(3):629-33. doi: 10.1158/0008-5472.CAN-10-2488. Epub 2011 Jan 25.
8
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.AKT 抑制缓解了受体酪氨酸激酶表达和活性的反馈抑制。
Cancer Cell. 2011 Jan 18;19(1):58-71. doi: 10.1016/j.ccr.2010.10.031. Epub 2011 Jan 6.
9
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.mTORC2 可以与核糖体结合,促进新生 Akt 多肽的共翻译磷酸化和稳定性。
EMBO J. 2010 Dec 1;29(23):3939-51. doi: 10.1038/emboj.2010.271. Epub 2010 Nov 2.
10
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases.致癌受体酪氨酸激酶激活的 Akt-RSK-S6 激酶信号网络。
Sci Signal. 2010 Aug 24;3(136):ra64. doi: 10.1126/scisignal.2000998.

Achieving specificity in Akt signaling in cancer.

作者信息

Toker Alex

机构信息

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

出版信息

Adv Biol Regul. 2012 Jan;52(1):78-87. doi: 10.1016/j.advenzreg.2011.09.020.

DOI:10.1016/j.advenzreg.2011.09.020
PMID:21986444
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3614006/
Abstract
摘要