Achieving specificity in Akt signaling in cancer.
作者信息
Toker Alex
机构信息
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Adv Biol Regul. 2012 Jan;52(1):78-87. doi: 10.1016/j.advenzreg.2011.09.020.
Abstract
摘要
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2
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