Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Ophthalmology. 2012 Jan;119(1):145-9. doi: 10.1016/j.ophtha.2011.06.035. Epub 2011 Oct 8.
The purpose of this study is to investigate whether children with congenital esotropia (CET) are more likely than controls to develop mental illness by early adulthood.
Retrospective, population-based cohort.
Children (aged <19 years) diagnosed with CET while residing in Olmsted County, Minnesota, from January 1, 1965, to December 31, 1994, and their 1-to-1 non-strabismic birth- and gender-matched controls.
The medical records of patients with esotropia and their controls were retrospectively reviewed for the subsequent development of psychiatric disease.
The development of mental illness and associated comorbidities among patients with CET and their controls.
A mental health disorder was diagnosed in 42 (33%) of the 127 patients with CET followed to a mean age of 20.4 years compared with 16% of controls (P = 0.002). Congenital esotropia increased the odds of developing a psychiatric illness 2.6 times (confidence interval, 1.5-4.8) compared with controls. The number of mental health diagnoses (P = 0.019) and the use of psychotropic medications (P = 0.015) were significantly more common among esotropic patients compared with non-strabismic controls.
Congenital esotropia, similar to those with intermittent exotropia or convergence insufficiency, increases the odds of developing mental illness by early adulthood 2.6 times compared with controls. The cause of this association does not seem to be associated with premature birth.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
本研究旨在探讨先天性内斜视（CET）患儿在成年早期是否比对照组更容易患上精神疾病。
回顾性、基于人群的队列研究。
19 岁以下，1965 年 1 月 1 日至 1994 年 12 月 31 日期间在明尼苏达州奥姆斯特德县被诊断为 CET 的儿童及其 1:1 非斜视出生和性别匹配的对照组。
回顾性查阅斜视患儿及其对照组的医疗记录，以了解其后续发展为精神疾病的情况。
患者与对照组的 CET 患者精神疾病的发展及其相关合并症。
42 名（33%）接受随访至平均 20.4 岁的 CET 患者被诊断出患有精神健康障碍，而对照组为 16%（P = 0.002）。与对照组相比，先天性内斜视使患精神病的几率增加了 2.6 倍（置信区间，1.5-4.8）。斜视患者的精神健康诊断次数（P = 0.019）和精神药物使用（P = 0.015）明显多于非斜视对照组。
与间歇性外斜视或集合不足相似，先天性内斜视使成年早期发展为精神疾病的几率增加了 2.6 倍。这种关联的原因似乎与早产无关。
作者没有与本文讨论的材料有关的专利或商业利益。
