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Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage.

作者信息

Britt-Compton B, Lin T T, Ahmed G, Weston V, Jones R E, Fegan C, Oscier D G, Stankovic T, Pepper C, Baird D M

出版信息

Leukemia. 2012 Apr;26(4):826-30. doi: 10.1038/leu.2011.281. Epub 2011 Oct 11.

DOI:10.1038/leu.2011.281
PMID:21986843
Abstract
摘要

相似文献

1
Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage.ATM基因发生突变以及11号染色体长臂缺失的慢性淋巴细胞白血病（CLL）患者的端粒严重缩短与疾病分期无关。
Leukemia. 2012 Apr;26(4):826-30. doi: 10.1038/leu.2011.281. Epub 2011 Oct 11.
2
A unique lethal blastoid transformation of B-cell chronic lymphocytic leukemia carrying ATM/11q deletion and trisomy 12.携带ATM/11q缺失和三体12的B细胞慢性淋巴细胞白血病的一种独特致死性母细胞样转化。
Leuk Res. 2009 Aug;33(8):e124-6. doi: 10.1016/j.leukres.2009.02.008. Epub 2009 Mar 6.
3
Late appearance of the 11q22.3-23.1 deletion involving the ATM locus in B-cell chronic lymphocytic leukemia and related disorders. Clinico-biological significance.B细胞慢性淋巴细胞白血病及相关疾病中涉及ATM基因座的11q22.3 - 23.1缺失的晚期出现。临床生物学意义。
Haematologica. 2002 Jan;87(1):44-51.
4
Bulky lymphadenopathy with poor clinical outcome is associated with ATM downregulation in B-cell chronic lymphocytic leukemia patients irrespective of 11q23 deletion.无论是否存在11q23缺失，在B细胞慢性淋巴细胞白血病患者中，具有不良临床预后的巨大淋巴结病与ATM下调有关。
Cancer Genet Cytogenet. 2007 Jan 15;172(2):120-6. doi: 10.1016/j.cancergencyto.2006.07.010.
5
Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.残留 ATM 等位基因的突变状态是慢性淋巴细胞白血病伴 11q 缺失患者细胞对化疗反应及生存情况的重要决定因素。
J Clin Oncol. 2007 Dec 1;25(34):5448-57. doi: 10.1200/JCO.2007.11.2649. Epub 2007 Oct 29.
6
Translocations as a mechanism for homozygous deletion of 13q14 and loss of the ATM gene in a patient with B-cell chronic lymphocytic leukemia.易位作为B细胞慢性淋巴细胞白血病患者13q14纯合缺失及ATM基因丢失的一种机制。
Cancer Genet Cytogenet. 2007 Apr 1;174(1):57-60. doi: 10.1016/j.cancergencyto.2006.11.006.
7
[Gene atm and chronic lymphocytic leukemia - review].[共济失调毛细血管扩张症突变基因与慢性淋巴细胞白血病——综述]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Oct;16(5):1242-6.
8
Increased transferrin receptor expression following 11q23 deletion as a mechanism of malignant progression in chronic lymphocytic leukemia.11q23缺失后转铁蛋白受体表达增加作为慢性淋巴细胞白血病恶性进展的一种机制
Med Hypotheses. 2006;66(3):509-12. doi: 10.1016/j.mehy.2005.08.056. Epub 2005 Dec 2.
9
A new minimal deleted region at 11q22.3 reveals the importance of interpretation of diminished FISH signals and the choice of probe for ATM deletion screening in chronic lymphocytic leukemia.一个新的 11q22.3 最小缺失区域揭示了在慢性淋巴细胞白血病中解读减少的 FISH 信号和选择用于 ATM 缺失筛选的探针的重要性。
Leuk Res. 2012 Mar;36(3):307-10. doi: 10.1016/j.leukres.2011.08.002. Epub 2011 Sep 28.
10
Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation status and previous treatment.B淋巴细胞慢性淋巴细胞白血病（B-CLL）患者中p53失活和ATM缺失与IgVH突变状态及既往治疗的关系
Leukemia. 2006 Jun;20(6):1159-61. doi: 10.1038/sj.leu.2404195.

引用本文的文献

1
ATM inhibition decreases ERK activation and is synergistic with ibrutinib in primary chronic lymphocytic leukemia cells.ATM抑制可降低原发性慢性淋巴细胞白血病细胞中的ERK激活，并且与依鲁替尼具有协同作用。
Blood Adv. 2025 May 27;9(10):2422-2427. doi: 10.1182/bloodadvances.2024014407.
2
DNA-PK hyperactivation occurs in deletion 11q chronic lymphocytic leukemia and is both a biomarker and therapeutic target for drug-resistant disease.DNA依赖蛋白激酶（DNA-PK）过度激活发生于11号染色体长臂缺失的慢性淋巴细胞白血病中，并且既是耐药性疾病的生物标志物又是治疗靶点。
Blood Cancer J. 2023 Jan 27;13(1):20. doi: 10.1038/s41408-022-00781-8.
3
Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes.
CLL 病程中 TP53 异常的演变与端粒长度变化有关。
BMC Cancer. 2022 Feb 3;22(1):137. doi: 10.1186/s12885-022-09221-z.
4
Chromothripsis in Chronic Lymphocytic Leukemia: A Driving Force of Genome Instability.慢性淋巴细胞白血病中的染色体碎裂：基因组不稳定的驱动因素
Front Oncol. 2021 Nov 26;11:771664. doi: 10.3389/fonc.2021.771664. eCollection 2021.
5
Telomere Dysfunction in Chronic Lymphocytic Leukemia.慢性淋巴细胞白血病中的端粒功能障碍
Front Oncol. 2021 Jan 15;10:612665. doi: 10.3389/fonc.2020.612665. eCollection 2020.
6
Massively parallel single-molecule telomere length measurement with digital real-time PCR.采用数字实时聚合酶链反应进行大规模平行单分子端粒长度测量。
Sci Adv. 2020 Aug 21;6(34). doi: 10.1126/sciadv.abb7944. Print 2020 Aug.
7
Telomere length and its correlation with gene mutations in chronic lymphocytic leukemia in a Korean population.端粒长度及其与韩国人群慢性淋巴细胞白血病基因突变的相关性。
PLoS One. 2019 Jul 23;14(7):e0220177. doi: 10.1371/journal.pone.0220177. eCollection 2019.
8
Telomere length predicts for outcome to FCR chemotherapy in CLL.端粒长度可预测 CLL 患者对 FCR 化疗的反应。
Leukemia. 2019 Aug;33(8):1953-1963. doi: 10.1038/s41375-019-0389-9. Epub 2019 Jan 30.
9
Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia.广泛的端粒侵蚀与巴雷特化生中的局部克隆性扩张一致。
PLoS One. 2017 Mar 31;12(3):e0174833. doi: 10.1371/journal.pone.0174833. eCollection 2017.
10
Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis.对共济失调毛细血管扩张症患者急性淋巴细胞白血病的基因组分析揭示了 ATM 突变与染色体重排之间的紧密联系。
Leukemia. 2017 Oct;31(10):2048-2056. doi: 10.1038/leu.2017.55. Epub 2017 Feb 15.