美国空乘人员队列的特定原因死亡率。
Cause-specific mortality among a cohort of U.S. flight attendants.
机构信息
Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA.
出版信息
Am J Ind Med. 2012 Jan;55(1):25-36. doi: 10.1002/ajim.21011. Epub 2011 Oct 10.
BACKGROUND
We evaluated mortality among 11,311 former U.S. flight attendants. The primary a priori outcomes of interest were breast cancer and melanoma.
METHODS
Vital status was ascertained through 2007, and life table analyses was conducted. Cumulative exposure to cosmic radiation and circadian rhythm disruption were estimated from work history data and historical published flight schedules.
RESULTS
All-cause mortality was less than expected among women but was elevated among men, primarily due to elevated HIV-related disease mortality. Mortality from breast cancer among women and melanoma was neither significantly elevated nor related to metrics of exposure. Mortality was elevated for non-Hodgkin's lymphoma among men; for alcoholism, drowning, and intentional self-harm among women; and for railway, water, and air transportation accidents.
CONCLUSIONS
We found no evidence of increased breast cancer or melanoma mortality. Limitations include reliance on mortality data and limited power resulting from few melanoma deaths and relatively short employment durations.
背景
我们评估了 11311 名美国前空姐的死亡率。主要的首要关注结局是乳腺癌和黑色素瘤。
方法
通过 2007 年确定了存活状态，并进行了生命表分析。从工作历史数据和历史发布的飞行时间表中估算了宇宙辐射和昼夜节律打乱的累积暴露量。
结果
所有原因的死亡率低于女性预期，但男性的死亡率升高，主要是由于 HIV 相关疾病的死亡率升高。女性的乳腺癌和黑色素瘤死亡率既没有显著升高，也与暴露指标无关。男性的非霍奇金淋巴瘤死亡率升高；女性的酒精中毒、溺水和故意自伤死亡率升高；铁路、水和航空运输事故的死亡率升高。
结论
我们没有发现乳腺癌或黑色素瘤死亡率增加的证据。局限性包括依赖于死亡率数据和由于黑色素瘤死亡人数较少以及相对较短的就业时间导致的有限效力。
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