帕金森病黑质区的高分辨率磁化率图。
High resolution magnetic susceptibility mapping of the substantia nigra in Parkinson's disease.
机构信息
Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, Nottingham, UK.
出版信息
J Magn Reson Imaging. 2012 Jan;35(1):48-55. doi: 10.1002/jmri.22752. Epub 2011 Oct 10.
PURPOSE
To determine if tissue magnetic susceptibility is a more direct marker of tissue iron content than other MR markers of iron. This study presents the first quantitative, in vivo measurements of the susceptibility of the substantia nigra in patients with Parkinson's disease.
MATERIALS AND METHODS
Nine patients and 11 controls were studied at 7 Tesla. Susceptibility maps were created by inverting the filtered phase maps associated with T2* weighted images.
RESULTS
On average, patients showed an increase in susceptibility of the pars compacta compared with controls, which correlates with the predicted increase in brain iron in Parkinson's disease. A rostral-caudal gradient in susceptibility was also observed in controls and patients.
CONCLUSION
Susceptibility mapping may provide a new tool for studying the development of Parkinson's disease.
目的
确定组织磁化率是否比其他铁磁共振标记物更能直接反映组织铁含量。本研究首次对帕金森病患者黑质组织的磁化率进行了定量的活体测量。
材料与方法
在 7T 磁共振扫描仪上对 9 名患者和 11 名健康对照者进行了研究。通过反转与 T2*加权图像相关的滤波相位图来生成磁化率图。
结果
与对照组相比，患者的壳核平均磁化率增加，这与帕金森病患者脑铁含量的预期增加相关。在对照组和患者中也观察到磁化率的头侧-尾侧梯度。
结论
磁化率图可能为研究帕金森病的发展提供一种新的工具。
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