Department of Gastroenterology, Princess Alexandra Hospital, Brisbane 4102 Queensland, Australia.
World J Gastroenterol. 2011 Sep 7;17(33):3856-8. doi: 10.3748/wjg.v17.i33.3856.
Clostridium septicum (C. septicum) gas gangrene is well documented in the literature, typically in the setting of trauma or immunosuppression. In this paper, we report a unique case of spontaneous clostridial myonecrosis in a patient with Crohn's disease and sulfasalazine-induced neutropenia. The patient presented with left thigh pain, vomiting and diarrhea. Blood tests demonstrated a profound neutropenia, and magnetic resonance imaging of the thigh confirmed extensive myonecrosis. The patient underwent emergency hip disarticulation, followed by hemicolectomy. C. septicum was cultured from the blood. Following completion of antibiotic therapy, the patient developed myonecrosis of the right pectoral muscle necessitating further debridement, and remains on lifelong prophylactic antibiotic therapy.
梭状芽孢杆菌性肌坏死症（C. septicum）气性坏疽在文献中有详细记载，通常发生在创伤或免疫抑制的情况下。在本文中，我们报告了一例克罗恩病和柳氮磺胺吡啶诱导的中性粒细胞减少症患者发生自发性梭状芽孢杆菌肌坏死的独特病例。患者表现为左大腿疼痛、呕吐和腹泻。血液检查显示严重的中性粒细胞减少症，大腿磁共振成像证实广泛的肌坏死。患者接受了紧急髋关节离断术，随后进行了半结肠切除术。从血液中培养出梭状芽孢杆菌。抗生素治疗完成后，患者发生右侧胸肌肌坏死，需要进一步清创，目前仍需终身预防性抗生素治疗。
