Rasmussen Peter, Ralfkiaer Elisabeth, Prause Jan Ulrik, Sjö Lene D, Siersma Volkert D, Heegaard Steffen
Department of Neuroscience and Pharmacology, Section of Eye Pathology, University of Copenhagen, Copenhagen, Denmark.
Arch Ophthalmol. 2011 Oct;129(10):1275-80. doi: 10.1001/archophthalmol.2011.270.
To characterize the clinicopathologic features of lacrimal gland lymphoma.
All cases of lacrimal gland lymphoma from January 1, 1975, through December 31, 2009, were retrieved from The Danish Registry of Pathology. Histologic specimens were reevaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed lymphoma were collected.
Twenty-seven patients with lacrimal gland lymphoma were identified. Eight of the patients were men and 19 were women; the median (range) age was 69 (43-87) years. The distribution of lymphoma subtypes was as follows: extranodal marginal zone lymphoma, 10 (37%); follicular lymphoma, 5 (19%); diffuse large B-cell lymphoma, 4 (15%); mantle cell lymphoma, 3 (11%); chronic lymphocytic leukemia/small lymphatic lymphoma, 2 (7%); and unclassified B-cell lymphoma, 3 (11%). Twenty-two patients (81%) had stage I or II lymphoma, 1 patient (4%) had stage III lymphoma, and 4 patients (15%) had stage IV lymphoma. Patients with stage I or II lymphoma were treated with radiotherapy (15 [67%]), chemotherapy (3 [14%]), chemotherapy plus radiotherapy (1 [5%]), and surgery (3 [14%]). Patients presenting with stage III or IV lymphoma were treated with chemotherapy alone. Complete remission was observed in 23 of the patients (85%), although 12 (44%) of these had a relapse, independent of subtype, stage, or treatment. The 5-year overall survival was 70%.
Malignant lymphoma of the lacrimal gland is relatively rare and is mostly prevalent in elderly women. The distribution of lacrimal gland lymphoma subtypes resembles that of lymphoma subtypes of the salivary glands. The majority of lacrimal gland lymphomas are low grade, and the prognosis is relatively good.
描述泪腺淋巴瘤的临床病理特征。
从丹麦病理登记处检索出1975年1月1日至2009年12月31日期间所有泪腺淋巴瘤病例。使用一组单克隆抗体对组织学标本进行重新评估。收集所有确诊淋巴瘤患者的临床资料。
共确定27例泪腺淋巴瘤患者。其中男性8例，女性19例；年龄中位数（范围）为69（43 - 87）岁。淋巴瘤亚型分布如下：结外边缘区淋巴瘤10例（37%）；滤泡性淋巴瘤5例（19%）；弥漫性大B细胞淋巴瘤4例（15%）；套细胞淋巴瘤3例（11%）；慢性淋巴细胞白血病/小淋巴细胞淋巴瘤2例（7%）；未分类B细胞淋巴瘤3例（11%）。22例（81%）患者为Ⅰ或Ⅱ期淋巴瘤，1例（4%）为Ⅲ期淋巴瘤，4例（15%）为Ⅳ期淋巴瘤。Ⅰ或Ⅱ期淋巴瘤患者接受放疗（15例[67%]）、化疗（3例[14%]）、化疗加放疗（1例[5%]）和手术（3例[14%]）治疗。Ⅲ或Ⅳ期淋巴瘤患者仅接受化疗。23例（85%）患者达到完全缓解，尽管其中12例（44%）复发，复发与亚型、分期或治疗无关。5年总生存率为70%。
泪腺恶性淋巴瘤相对罕见，多见于老年女性。泪腺淋巴瘤亚型分布与涎腺淋巴瘤亚型相似。大多数泪腺淋巴瘤为低级别，预后相对较好。
