Médecins Sans Frontières-Spain, Barcelona, Spain.
J Infect Dis. 2011 Nov;204 Suppl 3:S791-5. doi: 10.1093/infdis/jir297.
Testing an innovative therapy for filovirus hemorrhagic fever (FHF) in an outbreak setting may be years away. Moreover, beyond anecdotal evidence, little is known about best practice for outbreak case management. Currently, Médecins Sans Frontières and others provide FHF patients with basic supportive treatment. We describe and discuss treatment possibilities, challenges, and potential next steps for FHF outbreak case management. More comprehensive supportive treatment, including vital sign monitoring, intensive care components, and goal-directed interventions may contribute to improved clinical outcome; the feasibility and effectiveness of this more comprehensive supportive treatment should be assessed. Our outlined summary may assist future FHF outbreak case management teams to create collaborative platforms and develop relevant treatment protocols aimed at improving clinical outcome.
在疫情爆发的情况下，对丝状病毒出血热（FHF）的创新疗法进行测试可能还需要数年时间。此外，除了传闻证据外，对于疫情病例管理的最佳实践知之甚少。目前，无国界医生组织和其他组织为 FHF 患者提供基本的支持性治疗。我们描述并讨论了 FHF 疫情病例管理的治疗可能性、挑战和潜在的下一步措施。更全面的支持性治疗，包括生命体征监测、重症监护成分和目标导向干预措施，可能有助于改善临床结果；应评估这种更全面的支持性治疗的可行性和有效性。我们概述的总结可能有助于未来的 FHF 疫情病例管理团队创建协作平台，并制定旨在改善临床结果的相关治疗方案。
