Department of Preventive Medicine, Infectious Disease Clinical Research Program, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814-5119, USA.
J Infect Dis. 2011 Nov;204 Suppl 3:S810-6. doi: 10.1093/infdis/jir299.
The filoviruses Marburg and Ebola cause severe hemorrhagic fever (HF) in humans. Beginning with the 1967 Marburg outbreak, 30 epidemics, isolated cases, and accidental laboratory infections have been described in the medical literature. We reviewed those reports to determine the basic clinical and laboratory features of filoviral HF. The most detailed information was found in descriptions of patients treated in industrialized countries; except for the 2000 outbreak of Ebola Sudan HF in Uganda, reports of epidemics in central Africa provided little controlled or objective clinical data. Other than the case fatality rate, there were no clear differences in the features of the various filovirus infections. This compilation will be of value to medical workers responding to epidemics and to investigators attempting to develop animal models of filoviral HF. By identifying key unanswered questions and gaps in clinical data, it will help guide clinical research in future outbreaks.
马尔堡病毒和埃博拉病毒可引起人类严重的出血热（HF）。自 1967 年马尔堡病毒爆发以来，医学文献中已有 30 次暴发、孤立病例和意外实验室感染的描述。我们对这些报告进行了审查，以确定丝状病毒 HF 的基本临床和实验室特征。在描述在工业化国家治疗的患者时，可以找到最详细的信息；除了 2000 年乌干达爆发的埃博拉苏丹 HF 以外，在中非的疫情报告几乎没有提供任何对照或客观的临床数据。除了病死率之外，各种丝状病毒感染的特征没有明显差异。本汇编将对应对疫情的医务人员和试图开发丝状病毒 HF 动物模型的研究人员具有重要价值。通过确定关键的未解答问题和临床数据的空白，它将有助于指导未来疫情中的临床研究。
