Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
BMC Cancer. 2011 Oct 11;11:440. doi: 10.1186/1471-2407-11-440.
Recent studies have reported associations of DNA repair pathway gene variants and risk of various cancers and precancerous lesions, such as chronic atrophic gastritis (CAG).
A nested case-control study within the German population-based ESTHER cohort was conducted, including 533 CAG cases and 1054 controls. Polymorphisms in eleven DNA repair genes (APEX1, ERCC1, ERCC2/XPD, PARP1 and XRCC1), in CD3EAP/ASE-1 and PPP1R13L were analysed.
No association was disclosed for any of the analysed polymorphisms. Nor did stratified analyses according to ages < 65 and ≥ 65 years show any significant association with CAG risk.
The results of this large German case-control study do not reveal associations of DNA repair pathway polymorphisms and risk of CAG. On the basis of a large number of CAG cases, they do not support associations of DNA repair pathway SNPs with CAG risk, but suggest the need of larger studies to disclose or exclude potential weak associations, or of studies with full coverage of candidate genes.
最近的研究报告称，DNA 修复途径基因变异与各种癌症和癌前病变（如慢性萎缩性胃炎（CAG））的风险有关。
在德国基于人群的 ESTHER 队列中进行了一项巢式病例对照研究，包括 533 例 CAG 病例和 1054 例对照。分析了 11 个 DNA 修复基因（APEX1、ERCC1、ERCC2/XPD、PARP1 和 XRCC1）、CD3EAP/ASE-1 和 PPP1R13L 中的多态性。
未发现任何分析的多态性与 CAG 风险之间存在关联。根据年龄<65 岁和≥65 岁进行的分层分析也未显示与 CAG 风险有任何显著关联。
这项大型德国病例对照研究的结果并未揭示 DNA 修复途径多态性与 CAG 风险之间的关联。基于大量 CAG 病例，它们不支持 DNA 修复途径 SNP 与 CAG 风险之间的关联，但表明需要更大的研究来揭示或排除潜在的弱关联，或需要对候选基因进行全面覆盖的研究。
