氨基酸到功能化香豆素的简便转化。
A facile transformation of amino acids to functionalized coumarins.
机构信息
Department of Chemistry, Indian Institute of Science Education and Research, Pashan, Pune 411021, India.
出版信息
Org Biomol Chem. 2011 Dec 7;9(23):8089-95. doi: 10.1039/c1ob05815k. Epub 2011 Oct 11.
PMID:21989537
Abstract
The synthesis of novel chiral coumarins functionalized with proteinogenic amino acid side chains via N-protected γ-amino-β-keto esters and their incorporation into the cell permeable HIV-1 TAT peptide through the modified solid phase peptide synthesis are described.
摘要
通过 N-保护的γ-氨基-β-酮酯合成新型手性香豆素，并将其通过改良的固相肽合成法整合到细胞穿透性 HIV-1 TAT 肽中，描述了这些香豆素的合成。
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