Pharmacopsychiatry. 2012 Jan;45(1):28-30. doi: 10.1055/s-0031-1286344. Epub 2011 Oct 11.
Immunotherapy with alpha-interferon (IFN-α) is currently used as adjuvant treatment in patients with malignant melanoma. Psychiatric side effects such depression, mania or psychosis during treatment with IFN-α have been well documented in the literature. In comparison, however, data on interferon-induced obsessive-compulsive disorder are rare. We report here the case of a 23-year-old woman who developed obsessive-compulsive symptoms for the first time during interferon therapy after excision of a malignant melanoma.
免疫疗法用α-干扰素（IFN-α）目前被用作恶性黑色素瘤患者的辅助治疗。在 IFN-α治疗过程中出现的精神副作用，如抑郁、躁狂或精神病，在文献中有充分的记载。相比之下，干扰素引起的强迫症的数据则较为罕见。我们在此报告一例 23 岁女性，在恶性黑色素瘤切除后接受干扰素治疗时首次出现强迫症状。
