Wang S-G, Guo G-H, Fu Z-H, Zhou S-F
Burn Institute of the First Affiliated Hospital, An Hui Medical University, Nanchang, People's Republic of China.
Ann Burns Fire Disasters. 2006 Jun 30;19(2):88-94.
to investigate the beneficial effects of high-frequency oscillatory ventilation (HFOV) and partial liquid ventilation (PLV) in treating acute lung injury induced by steam inhalation.
a prospective, randomized, controlled, multiple group study.
an animal research centre laboratory in a university burns centre.
New Zealand rabbits (n = 30; 2.25 ± 0.25 kg) of either sex.
the animals were ventilated by HFOV with a mean airway pressure of 10 cm H (2)O, a frequency of 10 Hz, an amplitude of 20 cm H (2)O, an I:E ratio of 1:1, and an FiO (2)of 1.0. After the induction of acute lung injury by steam inhalation, the animals were randomly assigned to receive either HFOV alone or a combined therapy of HFOV + PLV. The animals were grouped as HFOV, HFOV + PLV, and control group (without ventilation after recovery from muscular relaxation).
arterial blood gases, cardiovascular haemodynamics, dynamic lung compliance, and total lung injury scores were measured. After steam inhalation, all three groups displayed low PaO (2)and low dynamic lung compliance. In the control group all the animals died within 3 h. In the HFOV and HFOV + PLV groups, all the animals displayed significant improvements in dynamic lung compliance, oxygenation, and histological outcomes; HFOV + PLV showed the best results.
in a New Zealand rabbit model of steam inhalation injury, HFOV improved oxygenation, increased dynamic lung compliance, and alleviated lung histological injury. Combined therapy with HFOV + PLV was clearly superior to that with HFOV alone during the observation period.
探讨高频振荡通气（HFOV）和部分液体通气（PLV）对蒸汽吸入所致急性肺损伤的治疗效果。
前瞻性、随机、对照、多组研究。
某大学烧伤中心的动物研究中心实验室。
新西兰兔（n = 30；体重2.25 ± 0.25千克），雌雄不限。
动物采用HFOV通气，平均气道压10 cm H₂O，频率10 Hz，振幅20 cm H₂O，吸呼比1:1，吸入氧分数1.0。在蒸汽吸入诱导急性肺损伤后，动物被随机分配接受单纯HFOV或HFOV + PLV联合治疗。动物分为HFOV组、HFOV + PLV组和对照组（肌肉松弛恢复后不进行通气）。
测量动脉血气、心血管血流动力学、动态肺顺应性和全肺损伤评分。蒸汽吸入后，三组均表现为低氧分压和低动态肺顺应性。对照组所有动物在3小时内死亡。在HFOV组和HFOV + PLV组，所有动物的动态肺顺应性、氧合和组织学结果均有显著改善；HFOV + PLV组效果最佳。
在新西兰兔蒸汽吸入损伤模型中，HFOV改善了氧合，增加了动态肺顺应性，减轻了肺组织学损伤。在观察期内，HFOV + PLV联合治疗明显优于单纯HFOV治疗。
