严重烧伤患者的免疫系统紊乱
Disorders of the immune system in severely burned patients.
作者信息
Fayazov A D, Shukurov S I, Shukurov B I, Sultanov B C, Namazov A N, Ruzimuratov D A
机构信息
Republican Research Center of Emergency Medicine, Tashkent, Republic of Uzbekistan.
出版信息
Ann Burns Fire Disasters. 2009 Sep 30;22(3):121-30.
Abstract
This paper analyses the results of immunological examinations of 124 patients with thermal injury. We examined indices of peripheral blood such us the size of the population of circulating T-lymphocytes (CD3), T-helpers (CD4), T-suppressors (CD8 and CD25), natural cell killers (CD16), transmembrane protein of apoptotic activity (CD16), B-lymphocytes, phagocyte activity of lymphocytes, and the level of serum antibody of the basic classes (Ig G, A, M). It was discovered that the burn disease was accompanied by deeply marked secondary immune deficiency primarily caused by all components of the active suppression of the cellular link of the immune system and reduction of phagocyte activity of neutrophils.
摘要
本文分析了124例热损伤患者的免疫学检查结果。我们检测了外周血指标，如循环T淋巴细胞（CD3）、辅助性T细胞（CD4）、抑制性T细胞（CD8和CD25）、自然杀伤细胞（CD16）、凋亡活性跨膜蛋白（CD16）、B淋巴细胞、淋巴细胞的吞噬活性以及基础类别血清抗体（IgG、A、M）水平。研究发现，烧伤疾病伴有明显的继发性免疫缺陷，主要是由免疫系统细胞环节的主动抑制的所有成分以及中性粒细胞吞噬活性降低所致。
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