LaVan F B, Hunt T K
Graduate Hospital, Philadelphia, Pennsylvania.
Clin Plast Surg. 1990 Jul;17(3):463-72.
Surgeons have been aware of the detrimental effect of ischemia and hypoxia on healing tissues. In order to assist repair in such circumstances, a variety of modalities including revascularization, flaps, and hyperbaric O2 have been developed. Although these are apparently successful from a clinical standpoint, only recently has experimental evidence demonstrated conclusively that oxygen is a controlling factor in wound repair. Furthermore, it is now clear that traditional expectations of repair can often be exceeded by increasing the partial pressure at which oxygen is supplied to wounds.
外科医生一直都知道缺血和缺氧对愈合组织的有害影响。为了在这种情况下辅助修复，已经开发了多种方法，包括血管重建、皮瓣和高压氧治疗。尽管从临床角度来看这些方法显然是成功的，但直到最近才有实验证据确凿地表明氧气是伤口修复的一个控制因素。此外，现在很清楚的是，通过提高向伤口供应氧气的分压，常常可以超出传统的修复预期。
