Tzaan Wen-Ching, Chen Hsien-Chih
Department of Neurosurgery, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung 204, Taiwan.
Adv Orthop. 2011;2011:602089. doi: 10.4061/2011/602089. Epub 2010 Nov 21.
Intervertebral disc (IVD) degeneration is a multifactorial process that is influenced by contributions from genetic predisposition, the aging phenomenon, lifestyle conditions, biomechanical loading and activities, and other health factors (such as diabetes). Attempts to decelerate disc degeneration using various techniques have been reported. However, to date, there has been no proven technique effective for broad clinical application. Granulocyte colony-stimulating factor (GCSF) is a growth factor cytokine that has been shown to enhance the availability of circulating hematopoietic stem cells to the brain and heart as well as their capacity for mobilization of mesenchymal bone marrow stem cells. GCSF also exerts significant increases in circulating neutrophils as well as potent anti-inflammatory effects. In our study, we hypothesize that GCSF can induce bone marrow stem cells differentiation and mobilization to regenerate the degenerated IVD. We found that GCSF had no contribution in disc regeneration or maintenance; however, there were cell proliferation within end plates. The effects of GCSF treatment on end plates might deserve further investigation.
椎间盘退变是一个多因素过程,受遗传易感性、衰老现象、生活方式、生物力学负荷与活动以及其他健康因素(如糖尿病)的影响。已有报道尝试使用各种技术来减缓椎间盘退变。然而,迄今为止,尚无经证实可广泛应用于临床的有效技术。粒细胞集落刺激因子(GCSF)是一种生长因子细胞因子,已被证明可提高循环造血干细胞向脑和心脏的供应及其动员间充质骨髓干细胞的能力。GCSF还可显著增加循环中性粒细胞数量,并具有强大的抗炎作用。在我们的研究中,我们假设GCSF可诱导骨髓干细胞分化和动员,以再生退变的椎间盘。我们发现GCSF对椎间盘再生或维持无作用;然而,终板内有细胞增殖。GCSF治疗对终板的影响可能值得进一步研究。