Department of Otolaryngology, Head and Neck Surgery, Lund University, Malmo, Sweden.
Rhinology. 2011 Oct;49(4):420-8. doi: 10.4193/Rhino11.101.
This study summarises the health-related quality of life (HRQOL) scores and absenteeism caused by sinus problems in patients awaiting surgery with the diagnoses recurrent acute rhinosinusitis (RARS), chronic rhinosinusitis with nasal polyps (CRS+NP) or CRS without nasal polyps (CRS-NP), in a prospective multi-centre study.
Two hundred and seven patients with RARS, CRS+NP or CRS-NP were enrolled. EP3OS definitions of CRS and NP were used. The patients completed the 22 Sinonasal Outcome Test (SNOT-22), the short-form 36-item questionnaire (SF-36), the Hospital Anxiety and Depression Scale (HAD) and a total Visual Analogue Scale (VAS) regarding rhinosinusitis symptoms.
SNOT-22 and VAS scores indicated severe disease. Comparison of the HRQOL scores in the three rhinosinusitis subgroups showed statistical differences in nine of the SNOT-22 items and in the SF-36 subscale of bodily pain. Mean scores of SF-36 were significantly lower than that of the normal Swedish population. According to the HAD scores, 28% of the patients had probable or possible anxiety or depression disorder. Fifty-seven percent of the patients reported absenteeism from work due to sinus problems.
RARS, CRS+NP and CRS-NP significantly decrease HRQOL. Some statistically significant differences in HRQOL were found between the three rhinosinusitis subgroups. Absenteeism due to chronic sinus conditions is considerable.
本研究总结了患有复发性急性鼻-鼻窦炎（RARS）、伴有鼻息肉的慢性鼻-鼻窦炎（CRS+NP）或不伴鼻息肉的慢性鼻-鼻窦炎（CRS-NP）的患者在等待手术时因鼻窦问题导致的健康相关生活质量（HRQOL）评分和缺勤情况。
共纳入 207 例 RARS、CRS+NP 或 CRS-NP 患者。采用 EP3OS 对 CRS 和 NP 进行定义。患者完成 22 项鼻-鼻窦结局测试（SNOT-22）、简短 36 项健康调查（SF-36）、医院焦虑和抑郁量表（HAD）以及一项关于鼻-鼻窦炎症状的总视觉模拟量表（VAS）。
SNOT-22 和 VAS 评分表明疾病严重。对三组鼻-鼻窦炎亚组的 HRQOL 评分进行比较，SNOT-22 的 9 项和 SF-36 躯体疼痛亚项的评分存在统计学差异。SF-36 的平均评分明显低于瑞典正常人群。根据 HAD 评分，28%的患者存在可能或确定的焦虑或抑郁障碍。57%的患者因鼻窦问题缺勤。
RARS、CRS+NP 和 CRS-NP 显著降低 HRQOL。在三组鼻-鼻窦炎亚组之间发现了一些 HRQOL 的统计学差异。由于慢性鼻窦疾病导致的缺勤相当可观。
