手性联萘酚催化的烯酮不对称共轭芳基硼化反应。
Binaphthol-catalyzed asymmetric conjugate arylboration of enones.
机构信息
Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, (GWC)2, Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1.
出版信息
Org Lett. 2011 Nov 4;13(21):5796-9. doi: 10.1021/ol202391r. Epub 2011 Oct 12.
PMID:21992717
Abstract
Conjugate addition of arylboronates to α,β-unsaturated ketones may be catalyzed by chiral binaphthols with enantioselectivities of up to 99:1. Best results were observed with 3,3'-dichloro-BINOL. This chemistry was applied to syntheses of intermediates for syntheses of (+)-indatraline and (+)-tolterodine.
摘要
芳基硼酸与α,β-不饱和酮的共轭加成可通过手性联萘酚催化，对映选择性高达 99:1。最好的结果是用 3,3'-二氯-BINOL 观察到的。这种化学方法被应用于(+)-吲哚拉林和(+)-托特罗定合成中间体的合成。
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