RAS 癌基因：编织致癌网络。
RAS oncogenes: weaving a tumorigenic web.
机构信息
Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA.
出版信息
Nat Rev Cancer. 2011 Oct 13;11(11):761-74. doi: 10.1038/nrc3106.
Abstract
RAS proteins are essential components of signalling pathways that emanate from cell surface receptors. Oncogenic activation of these proteins owing to missense mutations is frequently detected in several types of cancer. A wealth of biochemical and genetic studies indicates that RAS proteins control a complex molecular circuitry that consists of a wide array of interconnecting pathways. In this Review, we describe how RAS oncogenes exploit their extensive signalling reach to affect multiple cellular processes that drive tumorigenesis.
摘要
RAS 蛋白是细胞表面受体发出的信号通路的重要组成部分。由于错义突变，这些蛋白的致癌激活经常在几种类型的癌症中被检测到。大量的生化和遗传研究表明，RAS 蛋白控制着一个复杂的分子电路，由广泛的相互连接的途径组成。在这篇综述中，我们描述了 RAS 癌基因如何利用其广泛的信号传递来影响驱动肿瘤发生的多种细胞过程。
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