Gorovoy MD Eye Specialists, Ft. Myers, FL, USA.
Cornea. 2011 Dec;30(12):1414-8. doi: 10.1097/ICO.0b013e31820ca34b.
To report the long-term outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK).
A retrospective case series was conducted on 51 patients who underwent DSAEK 5 years ago. DSAEK was performed for Fuchs corneal dystrophy, pseudophakic or aphakic bullous keratopathy, or failed penetrating keratoplasty (PKP). Best spectacle-corrected visual acuity (BSCVA), endothelial cell counts (ECC), and current graft status were ascertained for the eyes included in the study. Episodes of rejection and need for repeat transplantation were also analyzed.
Forty-seven of 51 eyes had clear grafts at the most recent postoperative visit. There were 4 graft failures treated with repeat DSAEK, and regrafts are also clear to date. One eye had an episode of rejection that was successfully treated with topical steroids.
Long-term results of DSAEK were excellent. Grafts were clear despite lower than normal endothelial cell counts. To our knowledge, this is the longest running study of DSAEK outcomes to date.
报告 Descemet 撕囊自动化角膜内皮移植术（DSAEK）的长期结果。
对 51 例 5 年前接受 DSAEK 的患者进行回顾性病例系列研究。DSAEK 适用于 Fuchs 角膜营养不良、白内障或无晶状体眼泡状角膜病变、或穿透性角膜移植术（PKP）失败的患者。研究中纳入的眼最佳矫正视力（BSCVA）、内皮细胞计数（ECC）和当前移植物状态。还分析了排斥反应的发作和需要重复移植的情况。
在最近的术后随访中，51 只眼中有 47 只移植片透明。有 4 例移植失败，行重复 DSAEK 治疗，且再次移植片目前仍清晰。1 只眼发生 1 次排斥反应，经局部皮质类固醇治疗后成功。
DSAEK 的长期结果非常好。尽管内皮细胞计数低于正常，但移植物仍保持透明。据我们所知，这是迄今为止对 DSAEK 结果进行的最长研究。
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