标准早餐试验：胰高血糖素检测C肽储备的替代方法？

Standard breakfast test: an alternative to glucagon testing for C-peptide reserve?

作者信息

Escobar-Jiménez F, Herrera Pombo J L, Gómez-Villalba R, Nuñez del Carril J, Aguilar M, Rovira A

机构信息

Departamento de Medicina, Hospital Universitario de Granada, Spain.

出版信息

Horm Metab Res. 1990 Jun;22(6):339-41. doi: 10.1055/s-2007-1004915.

DOI:10.1055/s-2007-1004915

PMID:2199364

Abstract

We measured C-peptide after glucagon and breakfast tests to compare the effectiveness of both tests in evaluating residual beta cell function in normal and diabetic subjects. A significantly higher C-peptide response was elicited after standard breakfast in patients with insulin-dependent diabetes mellitus of less than two years' evolution, ranging from 0.12 +/- 0.07 to 0.83 +/- 0.18 ng/ml (P less than 0.05). In nonobese noninsulin-dependent diabetes mellitus the response ranged from 0.86 +/- 0.02 to 1.89 +/- 0.48 ng/ml (P less than 0.0025); in obese NIDDM from 1.02 +/- 0.37 to 1.55 +/- 0.46 ng/ml (P less than 0.05), and in normal subjects from 0.77 +/- 0.23 to 2.11 +/- 1.22 ng/ml (P less than 0.0025). We conclude that the standard breakfast test is a useful and practical approach to the study of residual beta cell function.

摘要

我们在胰高血糖素和早餐试验后测量了C肽，以比较这两种试验在评估正常人和糖尿病患者残余β细胞功能方面的有效性。病程小于两年的胰岛素依赖型糖尿病患者在标准早餐后引发的C肽反应显著更高，范围为0.12±0.07至0.83±0.18 ng/ml（P<0.05）。非肥胖非胰岛素依赖型糖尿病患者的反应范围为0.86±0.02至1.89±0.48 ng/ml（P<0.0025）；肥胖非胰岛素依赖型糖尿病患者的反应范围为1.02±0.37至1.55±0.46 ng/ml（P<0.05），正常受试者的反应范围为0.77±0.23至2.11±1.22 ng/ml（P<0.0025）。我们得出结论，标准早餐试验是研究残余β细胞功能的一种有用且实用的方法。