Department of Neonatology, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey.
Indian J Pediatr. 2012 Mar;79(3):389-91. doi: 10.1007/s12098-011-0581-z. Epub 2011 Oct 13.
In this case report the authors present an extremely low birth weight premature infant with neonatal brucellosis whose mother had been treated for brucellosis during pregnancy. Infant developed mild respiratory distress syndrome soon after birth. At 2nd wk of postnatal age findings of bronchopulmonary dysplasia were evident and she and her mother were diagnosed to have brucellosis at the same time. After commencement of antibrucellosis therapy and nonspesific treatment for bronchopulmonary dysplasia, infant was completely cured of the symptoms related to both brucellosis and bronchopulmonary dysplasia. The results of the present case and a review of the literature have let to conclude that Brucella might have role in development of prematurity and bronchoplumonary dysplasia. Since discovery of brucella bacilli in early periods of 20th century, fetotoxicity of brucella bacilli seems to increase gradually suggesting an increasing virulance of the bacilli or vanishing host defense of human beings.
本病例报告介绍了一例极低出生体重早产儿,其母亲在孕期患有布鲁氏菌病,新生儿患有布鲁氏菌病。婴儿出生后不久即出现轻度呼吸窘迫综合征。在出生后第 2 周,出现支气管肺发育不良的表现,婴儿及其母亲同时被诊断为布鲁氏菌病。在开始抗布鲁氏菌病治疗和支气管肺发育不良的非特异性治疗后,婴儿完全治愈了与布鲁氏菌病和支气管肺发育不良相关的症状。本病例的结果和文献复习的结果表明,布鲁氏菌可能在早产和支气管肺发育不良的发生中起作用。自 20 世纪早期发现布鲁氏菌以来,布鲁氏菌的胎儿毒性似乎逐渐增加,表明细菌的毒力逐渐增加或人类的宿主防御逐渐消失。