Ali Shahzad, Akhter Shamim, Neubauer Heinrich, Scherag André, Kesselmeier Miriam, Melzer Falk, Khan Iahtasham, El-Adawy Hosny, Azam Asima, Qadeer Saima, Ali Qurban
University of Veterinary and Animal Sciences, Lahore, Pakistan.
Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan.
BMC Infect Dis. 2016 Sep 2;16(1):468. doi: 10.1186/s12879-016-1799-1.
Brucella species occasionally cause spontaneous human abortion. Brucella can be transmitted commonly through the ingestion of raw milk or milk products. The objective of this study was to determine the sero-prevalence of and to identify potential risk factors for brucellosis in pregnant women from Rawalpindi, Pakistan.
We conducted a cross-sectional study at the Gynecology Outdoor Patient department of the Benazir Bhutto Hospital, Rawalpindi, Pakistan from March to June 2013. Data related to potential risk factors and clinical history was collected by individual interviews on the blood sampling day. The 429 serum samples collected were initially screened by Rose Bengal Plate Agglutination test for the detection of Brucella antibodies. We applied standard descriptive statistics and logistic regression analyses.
Twenty five (5.8 %; 95 % confidence interval (CI): 3.8 % -8.5 %) serum samples were found to be seropositive. Brucellosis-related clinical symptoms were recorded in various seropositive cases. Animal contact, raw milk consumption, having an abortion history and the experience of an intrauterine fetal death were associated with seropositivity for brucellosis in univariate analyses (all p <0.05). In multiple logistic regression models only the contact with animals remained as independent and robust risk factor (odds ratio 5.21; 95 % CI: 1.88-13.75; p = 0.001) for seropositivity.
Brucellosis is a serious threat for pregnant women and their unborn children in Pakistan. Pregnant women having brucellosis-related symptoms or previous history of abortions, miscarriages, intrauterine fetal death and other brucellosis-related manifestations should be screened for brucellosis - especially those exposed to animals given the increased risk - and medication should be administered according to state of the art.
布鲁氏菌属偶尔会导致人类自然流产。布鲁氏菌通常通过摄入生牛奶或奶制品传播。本研究的目的是确定巴基斯坦拉瓦尔品第孕妇布鲁氏菌病的血清阳性率，并识别其潜在风险因素。
2013年3月至6月，我们在巴基斯坦拉瓦尔品第贝娜齐尔·布托医院的妇科门诊进行了一项横断面研究。在采血当天通过个人访谈收集与潜在风险因素和临床病史相关的数据。对收集的429份血清样本最初采用虎红平板凝集试验筛查布鲁氏菌抗体。我们应用了标准描述性统计和逻辑回归分析。
发现25份（5.8%；95%置信区间（CI）：3.8%-8.5%）血清样本呈血清阳性。在各种血清阳性病例中记录到了与布鲁氏菌病相关的临床症状。在单因素分析中，与动物接触、饮用生牛奶、有流产史以及有胎儿宫内死亡经历均与布鲁氏菌病血清阳性相关（所有p<0.05）。在多因素逻辑回归模型中，仅与动物接触仍是血清阳性的独立且有力的风险因素（比值比5.21；95%CI：1.88-13.75；p=0.001）。
在巴基斯坦，布鲁氏菌病对孕妇及其未出生的孩子构成严重威胁。有与布鲁氏菌病相关症状或既往有流产、死产、胎儿宫内死亡及其他布鲁氏菌病相关表现的孕妇应接受布鲁氏菌病筛查——尤其是那些接触动物的孕妇，因其风险增加——并应根据最新技术进行药物治疗。
