Department of Gastroenterology, The First Hospital of Jilin University, Changchun 130021, PR China.
Mol Med Rep. 2012 Jan;5(1):184-9. doi: 10.3892/mmr.2011.627. Epub 2011 Oct 11.
The impact of adefovir dipivoxil (ADV) treatment on the immune system in patients with chronic hepatitis B (CHB) is unknown. The present study was designed to determine the expression of six cytokines, IL-2, IFN-γ, TNF-α, IL-4, IL-6 and IL-10, and their correlation with liver functions and clinical responses to ADV treatment. A total of 22 CHB patients were treated with ADV at a daily oral dose of 10 mg. Six cytokines, as well as AST, ALT and HBV DNA levels in blood samples were quantified prior to and following the treatment. A total of 10 healthy volunteers were enrolled as the control group. The six cytokines in CHB patients were significantly lower than in healthy individuals, and were increased significantly following 4, 12 and 24 weeks of ADV treatment. Although ALT, AST and HBV DNA were reduced following treatment, no correlation was found between these six cytokines and liver function or HBV DNA levels. The levels of the six cytokines in the group of patients with a complete clinical response were significantly higher than those in the group with a partial clinical response. ADV treatment increases the immunity of Th1/Th2 cells in CHB patients, and the increases in cytokines partly reflect the efficacy of the antiviral treatment.
阿德福韦酯（ADV）治疗对慢性乙型肝炎（CHB）患者免疫系统的影响尚不清楚。本研究旨在确定六种细胞因子（IL-2、IFN-γ、TNF-α、IL-4、IL-6 和 IL-10）的表达及其与肝功能和 ADV 治疗临床应答的相关性。22 例 CHB 患者接受 ADV 治疗，每日口服 10mg。治疗前后检测血样中六种细胞因子以及 AST、ALT 和 HBV DNA 水平。共招募 10 名健康志愿者作为对照组。CHB 患者的六种细胞因子明显低于健康个体，且经 ADV 治疗 4、12 和 24 周后明显升高。尽管 ALT、AST 和 HBV DNA 治疗后降低，但与肝功能或 HBV DNA 水平均无相关性。完全临床应答组患者六种细胞因子水平明显高于部分临床应答组。ADV 治疗可增强 CHB 患者 Th1/Th2 细胞的免疫功能，细胞因子的增加部分反映了抗病毒治疗的疗效。
