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Augmented intratubular renin and prorenin expression in the medullary collecting ducts of the kidney as a novel mechanism of angiotensin II-induced hypertension.

作者信息

Zhuo Jia L

出版信息

Am J Physiol Renal Physiol. 2011 Dec;301(6):F1193-4. doi: 10.1152/ajprenal.00555.2011. Epub 2011 Oct 12.

DOI:10.1152/ajprenal.00555.2011
PMID:21993882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3233873/
Abstract
摘要

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Augmented intratubular renin and prorenin expression in the medullary collecting ducts of the kidney as a novel mechanism of angiotensin II-induced hypertension.肾髓质集合管中肾小管内肾素和肾素原表达增加作为血管紧张素II诱导高血压的新机制。
Am J Physiol Renal Physiol. 2011 Dec;301(6):F1193-4. doi: 10.1152/ajprenal.00555.2011. Epub 2011 Oct 12.
2
Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats.在慢性血管紧张素 II 输注性高血压大鼠中，肾素排泄增加与尿血管紧张素 II 水平升高有关。
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Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin-angiotensin-aldosterone system activity and the efficacy of renin-angiotensin-aldosterone system blockade in the kidney.尿肾素而非血管紧张素原或醛固酮反映了肾脏肾素-血管紧张素-醛固酮系统的活性和肾素-血管紧张素-醛固酮系统阻断剂在肾脏中的疗效。
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Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F505-14. doi: 10.1152/ajprenal.00587.2012. Epub 2013 Jan 9.
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Enhancement of renin and prorenin receptor in collecting duct of Cyp1a1-Ren2 rats may contribute to development and progression of malignant hypertension.Cyp1a1-Ren2 大鼠集合管中肾素和肾素原受体的增强可能有助于恶性高血压的发展和进展。
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Recent Updates on the Proximal Tubule Renin-Angiotensin System in Angiotensin II-Dependent Hypertension.血管紧张素II依赖性高血压中近端肾小管肾素-血管紧张素系统的最新进展
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Structural libraries of protein models for multiple species to understand evolution of the renin-angiotensin system.用于多种物种的蛋白质模型结构库，以了解肾素-血管紧张素系统的进化。
Gen Comp Endocrinol. 2015 May 1;215:106-16. doi: 10.1016/j.ygcen.2014.09.010. Epub 2014 Sep 26.
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New frontiers in the intrarenal Renin-Angiotensin system: a critical review of classical and new paradigms.肾脏内肾素-血管紧张素系统的新前沿：对经典和新范例的批判性回顾。
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(Pro)renin receptor mediates both angiotensin II-dependent and -independent oxidative stress in neuronal cells.(原)肾素受体介导神经元细胞中血管紧张素 II 依赖性和非依赖性氧化应激。
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本文引用的文献

1
Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats.在慢性血管紧张素 II 输注性高血压大鼠中，肾素排泄增加与尿血管紧张素 II 水平升高有关。
Am J Physiol Renal Physiol. 2011 Dec;301(6):F1195-201. doi: 10.1152/ajprenal.00339.2011. Epub 2011 Aug 24.
2
New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II.关于肾内肾素-血管紧张素系统的新见解和新视角：关注内泌/细胞内血管紧张素 II。
Peptides. 2011 Jul;32(7):1551-65. doi: 10.1016/j.peptides.2011.05.012. Epub 2011 Jun 14.
3
Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats.在慢性血管紧张素 II 依赖性高血压大鼠的集合管和尿液中，（前）肾素受体的可溶性形式增加。
Hypertension. 2011 Apr;57(4):859-64. doi: 10.1161/HYPERTENSIONAHA.110.167957. Epub 2011 Feb 14.
4
Intratubular renin-angiotensin system in hypertension.高血压中的肾小管内肾素-血管紧张素系统
Hypertension. 2011 Mar;57(3):355-62. doi: 10.1161/HYPERTENSIONAHA.110.163519. Epub 2011 Jan 31.
5
Enhancement of renin and prorenin receptor in collecting duct of Cyp1a1-Ren2 rats may contribute to development and progression of malignant hypertension.Cyp1a1-Ren2 大鼠集合管中肾素和肾素原受体的增强可能有助于恶性高血压的发展和进展。
Am J Physiol Renal Physiol. 2011 Feb;300(2):F581-8. doi: 10.1152/ajprenal.00433.2010. Epub 2010 Nov 10.
6
Renin release: sites, mechanisms, and control.肾素释放：部位、机制和调控。
Annu Rev Physiol. 2011;73:377-99. doi: 10.1146/annurev-physiol-012110-142238.
7
Collecting duct renin is upregulated in both kidneys of 2-kidney, 1-clip goldblatt hypertensive rats.在二肾一夹型Goldblatt高血压大鼠的双侧肾脏中，集合管肾素上调。
Hypertension. 2008 Jun;51(6):1590-6. doi: 10.1161/HYPERTENSIONAHA.108.110916. Epub 2008 Apr 21.
8
In vivo regulation of AT1a receptor-mediated intracellular uptake of [125I]Val5-ANG II in the kidneys and adrenals of AT1a receptor-deficient mice.AT1a受体缺陷小鼠肾脏和肾上腺中AT1a受体介导的[125I]缬氨酸5-血管紧张素II细胞内摄取的体内调节
Am J Physiol Renal Physiol. 2008 Feb;294(2):F293-302. doi: 10.1152/ajprenal.00398.2007. Epub 2007 Nov 28.
9
Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice.AT1a受体的基因缺失减弱了AT1a受体缺陷小鼠肾脏中血管紧张素II的细胞内蓄积。
Am J Physiol Renal Physiol. 2007 Aug;293(2):F586-93. doi: 10.1152/ajprenal.00489.2006. Epub 2007 May 30.
10
AT1 receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats.血管紧张素II依赖性高血压大鼠中，AT1受体介导的集合管肾素增强作用。
Am J Physiol Renal Physiol. 2005 Sep;289(3):F632-7. doi: 10.1152/ajprenal.00462.2004. Epub 2005 May 3.