Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD 21205, USA.
ALTEX. 2011;28(3):183-209. doi: 10.14573/altex.2011.3.183.
The European cosmetics legislation foresees a review in 2011 and possible postponement of the 2013 marketing ban to enforce the testing ban for systemic and repeated-dose animal tests. For this purpose, a 119-page report commissioned by the European Commission was published recently. Here, a group of 17 independent experts from the US, Europe, and Japan was brought together to evaluate the report. The expert panel strongly endorsed the report and its conclusions. A number of important options not considered were identified; these do not, however, affect the overall conclusions regarding the current lack of availability of a full replacement, especially for the areas of repeated dose toxicity, carcinogenicity testing, and reproductive toxicity, though a roadmap for change is emerging. However, some of these options may provide adequate data for replacement of some animal studies in the near future pending validation. Various recommendations expand the original report. The reviewers agree with the report that there is greater promise in the short term for the areas of sensitization and toxicokinetics. Additional opportunities lie in more global collaborations and the inclusion of other industry sectors.
欧盟化妆品法规预计将在 2011 年进行审查，并可能将 2013 年的市场禁令推迟，以执行对系统和重复剂量动物试验的测试禁令。为此，欧盟委员会最近发布了一份 119 页的报告。在这里，来自美国、欧洲和日本的 17 位独立专家组成了一个小组来评估该报告。专家组强烈支持该报告及其结论。确定了一些未被考虑的重要选项；然而，这些并不影响关于目前缺乏全面替代方案的总体结论，特别是在重复剂量毒性、致癌性测试和生殖毒性方面，尽管正在出现变革的路线图。然而，其中一些选项可能会为在不久的将来验证后替代一些动物研究提供足够的数据。各种建议扩展了原始报告。审查员同意报告的观点，即在短期内，致敏和毒代动力学领域有更大的希望。更多的全球合作和包括其他行业部门也将提供更多机会。
