Department of Neurosurgery, Stony Brook University Medical Center, Stony Brook, New York, New York 11794-8122, USA.
J Neurointerv Surg. 2009 Jul;1(1):35-9. doi: 10.1136/jnis.2009.000125. Epub 2009 Jul 3.
Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) is a randomized trial comparing aggressive medical management alone with aggressive medical management in combination with angioplasty and stenting using the Gateway-Wingspan system in patients with symptomatic, high-grade, intracranial stenosis. This trial represents a landmark in the maturation of the field of neurointervention, establishing a foundation for evidenced-based practice. We review the natural history of symptomatic intracranial stenosis when treated medically, the available interventional therapies and the rationale for the design of the SAMMPRIS trial.
支架置入和强化药物治疗预防颅内狭窄患者卒中复发（SAMMPRIS）研究是一项随机临床试验，比较单纯强化药物治疗与强化药物联合血管成形术和支架置入治疗症状性、重度颅内狭窄患者的疗效。该试验代表神经介入领域的一个里程碑，为循证实践奠定了基础。我们回顾了症状性颅内狭窄经药物治疗的自然病程，以及现有的介入治疗方法和 SAMMPRIS 试验设计的原理。
