Department of Neurology, University Duisburg-Essen, Essen, Germany.
Cephalalgia. 2011 Dec;31(16):1664-72. doi: 10.1177/0333102411425866. Epub 2011 Oct 12.
Cluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (eCH) or chronic cluster headache (cCH) causing significant burden of disease and requiring attack therapy and prophylactic treatment.
Treatment costs (direct costs) due to healthcare utilisation, as well as costs caused by disability and reduction in earning capacity (indirect costs), were obtained using a questionnaire in CH patients treated in a tertiary headache centre based at the University Duisburg-Essen over a 6-month period.
A total 179 patients (72 cCH, 107 eCH) were included. Mean attack frequency was 3.5 ± 2.5 per day. Mean direct and indirect costs for one person were €5963 in the 6-month period. Direct costs were positively correlated with attack frequency (r = 0.467, p < 0.001). Burden of disease measured with HIT-6 showed a significant correlation with attack frequency (r = 0.467, p < 0.001). Twenty-four (13.4%) of the participants were disabled and not able to work.
CH leads to major socioeconomic impact on patients as well as society due to direct healthcare costs and indirect costs caused by loss of working capacity.
丛集性头痛（CH）是最常见的三叉神经自主头痛。CH 可表现为发作性（eCH）或慢性丛集性头痛（cCH），导致疾病负担显著，并需要发作期治疗和预防性治疗。
在杜伊斯堡-埃森大学的一个三级头痛中心接受治疗的 CH 患者在 6 个月期间使用问卷获得了由于医疗保健利用而产生的治疗费用（直接成本），以及因残疾和工作能力下降而产生的费用（间接成本）。
共纳入 179 名患者（72 名 cCH，107 名 eCH）。平均发作频率为每天 3.5±2.5 次。在 6 个月期间，一个人的直接和间接成本平均为 5963 欧元。直接成本与发作频率呈正相关（r=0.467，p<0.001）。用 HIT-6 测量的疾病负担与发作频率呈显著相关性（r=0.467，p<0.001）。24 名（13.4%）参与者残疾，无法工作。
由于直接医疗保健成本和丧失工作能力造成的间接成本，CH 给患者和社会带来了重大的社会经济影响。
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