Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan.
Viruses. 2009 Dec;1(3):818-31. doi: 10.3390/v1030818. Epub 2009 Nov 6.
Hepatitis delta virus (HDV) is a distant relative of plant viroids in the animal world. Similar to plant viroids, HDV replicates its circular RNA genome using a double rolling-circle mechanism. Nevertheless, the production of hepatitis delta antigen (HDAg), which is indispensible for HDV replication, is a unique feature distinct from plant viroids, which do not encode any protein. Here the HDV RNA replication cycle is reviewed, with emphasis on the function of HDAg in modulating RNA replication and the nature of the enzyme involved.
乙型肝炎 delta 病毒（HDV）是动物世界中植物类病毒的远亲。与植物类病毒类似，HDV 使用双链滚环机制复制其环状 RNA 基因组。然而，产生乙型肝炎 delta 抗原（HDAg）是 HDV 复制所必需的，这是与不编码任何蛋白质的植物类病毒的独特特征。本文综述了 HDV RNA 复制周期，重点介绍了 HDAg 在调节 RNA 复制中的作用以及涉及的酶的性质。
