Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Viruses. 2020 Jun 16;12(6):648. doi: 10.3390/v12060648.
Hepatitis delta virus (HDV) and hepatitis B virus (HBV) are blood-borne viruses that infect human hepatocytes and cause significant liver disease. Infections with HBV are more damaging when there is a coinfection with HDV. The genomes and modes of replication of these two viruses are fundamentally different, except for the fact that, in nature, HDV replication is dependent upon the envelope proteins of HBV to achieve assembly and release of infectious virus particles, ones that use the same host cell receptor. This review focuses on what has been found of the various ways, natural and experimental, by which HDV particles can be assembled and released. This knowledge has implications for the prevention and treatment of HDV infections, and maybe for an understanding of the origin of HDV.
丁型肝炎病毒 (HDV) 和乙型肝炎病毒 (HBV) 是通过血液传播的病毒，感染人类肝细胞并导致严重的肝脏疾病。当 HBV 感染合并 HDV 感染时，感染的破坏性更大。这两种病毒的基因组和复制方式有根本的不同，除了一个事实，即 HDV 的复制实际上依赖于 HBV 的包膜蛋白来实现组装和释放具有感染性的病毒颗粒，这些颗粒使用相同的宿主细胞受体。这篇综述重点介绍了在自然和实验条件下发现的丁型肝炎病毒颗粒组装和释放的各种方式。这些知识对于丁型肝炎病毒感染的预防和治疗具有重要意义，也可能有助于理解丁型肝炎病毒的起源。
