逆转录酶和细胞因子：HIV-1 逆转录的调节因子。
Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription.
机构信息
Division of Infectious Diseases, Queensland Institute of Medical Research, Brisbane, QLD, Australia; E-Mails:
出版信息
Viruses. 2009 Dec;1(3):873-94. doi: 10.3390/v1030873. Epub 2009 Nov 10.
Abstract
There is ample evidence that synthesis of HIV-1 proviral DNA from the viral RNA genome during reverse transcription requires host factors. However, only a few cellular proteins have been described in detail that affect reverse transcription and interact with reverse transcriptase (RT). HIV-1 integrase is an RT binding protein and a number of IN-binding proteins including INI1, components of the Sin3a complex, and Gemin2 affect reverse transcription. In addition, recent studies implicate the cellular proteins HuR, AKAP149, and DNA topoisomerase I in reverse transcription through an interaction with RT. In this review we will consider interactions of reverse transcription complex with viral and cellular factors and how they affect the reverse transcription process.
摘要
有充分的证据表明，HIV-1 前病毒 DNA 的合成来自于病毒 RNA 基因组在逆转录过程中需要宿主因子。然而，只有少数几个细胞蛋白被详细描述，这些蛋白影响逆转录并与逆转录酶（RT）相互作用。HIV-1 整合酶是 RT 结合蛋白，有许多 IN 结合蛋白，包括 INI1、Sin3a 复合物的组成部分和 Gemin2，这些都影响逆转录。此外，最近的研究表明，细胞蛋白 HuR、AKAP149 和 DNA 拓扑异构酶 I 通过与 RT 的相互作用参与逆转录。在这篇综述中，我们将考虑逆转录复合物与病毒和细胞因子的相互作用，以及它们如何影响逆转录过程。
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