Reverse transcription complex: the key player of the early phase of HIV replication.
作者信息
Iordanskiy Sergey, Bukrinsky Michael
机构信息
The George Washington University, Washington, DC, USA ; The D.I. Ivanovsky Institute of Virology, Moscow, Russia.
出版信息
Future Virol. 2007 Jan 1;2(1):49-64. doi: 10.2217/17460794.2.1.49.
Abstract
摘要
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Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity.亲环素A使1型人类免疫缺陷病毒对旧世界猴的TRIM5α抗病毒活性敏感，但对人类的TRIM5α抗病毒活性不敏感。
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Saturation of TRIM5 alpha-mediated restriction of HIV-1 infection depends on the stability of the incoming viral capsid.TRIM5α介导的对HIV-1感染的限制作用的饱和取决于进入的病毒衣壳的稳定性。
Virology. 2006 Jul 5;350(2):493-500. doi: 10.1016/j.virol.2006.03.013. Epub 2006 Apr 19.
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