Department of Microbiology and Immunology, Des Moines University, Des Moines, IA, USA.
Viruses. 2009 Dec;1(3):965-78. doi: 10.3390/v1030965. Epub 2009 Nov 18.
Apoptosis is triggered as an intrinsic defense against numerous viral infections. Almost every virus encodes apoptotic modulators, and the herpes simplex viruses (HSV) are no exception. During HSV infection, there is an intricate balance between pro- and anti-apoptotic factors that delays apoptotic death until the virus has replicated. Perturbations in the apoptotic balance can cause premature cell death and have the potential to dramatically alter the outcome of infection. Recently, certain cellular genes have been shown to regulate sensitivity to HSV-dependent apoptosis. This review summarizes current knowledge of the cellular genes that impact the apoptotic balance during HSV infection.
细胞凋亡作为一种内在防御机制被触发,以抵抗多种病毒感染。几乎每一种病毒都编码凋亡调节剂,单纯疱疹病毒(HSV)也不例外。在 HSV 感染过程中,存在着促凋亡和抗凋亡因子之间的复杂平衡,这种平衡会延迟凋亡性死亡,直到病毒完成复制。凋亡平衡的破坏可能导致过早的细胞死亡,并有可能显著改变感染的结果。最近,某些细胞基因已被证明可以调节对 HSV 依赖性细胞凋亡的敏感性。这篇综述总结了目前关于细胞基因在 HSV 感染过程中影响凋亡平衡的知识。