疱疹病毒感染与 PML 核体介导的宿主防御之间的相互作用。
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
机构信息
Institute for Clinical and Molecular Virology, University of Erlangen-Nuremberg, Schlossgarten 4, 91054 Erlangen, Germany; E-Mail:
出版信息
Viruses. 2009 Dec;1(3):1240-64. doi: 10.3390/v1031240. Epub 2009 Dec 15.
Abstract
In recent studies we and others have identified the cellular proteins PML, hDaxx, and Sp100, which form a subnuclear structure known as nuclear domain 10 (ND10) or PML nuclear bodies (PML-NBs), as host restriction factors that counteract herpesviral infections by inhibiting viral replication at different stages. The antiviral function of ND10, however, is antagonized by viral regulatory proteins (e.g., ICP0 of herpes simplex virus; IE1 of human cytomegalovirus) which induce either a modification or disruption of ND10. This review will summarize the current knowledge on how viral replication is inhibited by ND10 proteins. Furthermore, herpesviral strategies to defeat this host defense mechanism are discussed.
摘要
在最近的研究中，我们和其他人已经确定了细胞蛋白 PML、hDaxx 和 Sp100，它们形成了一个核内结构，称为核域 10（ND10）或 PML 核体（PML-NBs），作为宿主限制因子，通过在不同阶段抑制病毒复制来抵抗疱疹病毒感染。然而，ND10 的抗病毒功能受到病毒调节蛋白（例如单纯疱疹病毒的 ICP0；人巨细胞病毒的 IE1）的拮抗，这些调节蛋白诱导 ND10 的修饰或破坏。这篇综述将总结目前关于 ND10 蛋白如何抑制病毒复制的知识。此外，还讨论了疱疹病毒战胜这种宿主防御机制的策略。
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本文引用的文献
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2
Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection.
Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):286-95. doi: 10.1016/j.bbagrm.2009.08.001. Epub 2009 Aug 12.
3
Complementation of a herpes simplex virus ICP0 null mutant by varicella-zoster virus ORF61p.
J Virol. 2009 Oct;83(20):10637-43. doi: 10.1128/JVI.01144-09. Epub 2009 Aug 5.
4
Kaposi's sarcoma-associated herpesvirus protein LANA2 disrupts PML oncogenic domains and inhibits PML-mediated transcriptional repression of the survivin gene.
J Virol. 2009 Sep;83(17):8849-58. doi: 10.1128/JVI.00339-09. Epub 2009 Jun 24.
5
Lytic infection of permissive cells with human cytomegalovirus is regulated by an intrinsic 'pre-immediate-early' repression of viral gene expression mediated by histone post-translational modification.
J Gen Virol. 2009 Oct;90(Pt 10):2364-2374. doi: 10.1099/vir.0.012526-0. Epub 2009 Jun 10.
6
Human cytomegalovirus protein pp71 induces Daxx SUMOylation.
J Virol. 2009 Jul;83(13):6591-8. doi: 10.1128/JVI.02639-08. Epub 2009 Apr 15.
7
Differential functions of interferon-upregulated Sp100 isoforms: herpes simplex virus type 1 promoter-based immediate-early gene suppression and PML protection from ICP0-mediated degradation.
J Virol. 2009 May;83(10):5168-80. doi: 10.1128/JVI.02083-08. Epub 2009 Mar 11.
8
PML nuclear bodies as sites of epigenetic regulation.
Front Biosci (Landmark Ed). 2009 Jan 1;14(4):1325-36. doi: 10.2741/3311.
9
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10
Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection.
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