Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195-7720, USA.
Viruses. 2010 Jan;2(1):244-261. doi: 10.3390/v2010244. Epub 2010 Jan 19.
Numerous human genetic and acquired diseases could be corrected or ameliorated if viruses are harnessed to safely and effectively deliver therapeutic genes to diseased cells and tissues in vivo. Innate immune and inflammatory response represents one of the key stumbling blocks during the development of viral-based therapies. In this review, current data on the early innate immune responses to viruses and to the most commonly used gene therapy vectors (using adenovirus and adeno-associated virus) will be discussed. Recent findings in the field may help develop new approaches to moderate these innate immune anti-viral responses and thus improve the safety of viral vectors for human gene therapy applications.
如果能够利用病毒将治疗基因安全有效地递送到体内患病细胞和组织中，许多人类遗传性和获得性疾病都可以得到纠正或改善。先天免疫和炎症反应是病毒治疗发展过程中的关键障碍之一。在这篇综述中，将讨论目前关于病毒和最常用的基因治疗载体（使用腺病毒和腺相关病毒）的早期先天免疫反应的相关数据。该领域的最新发现可能有助于开发新方法来调节这些先天免疫抗病毒反应，从而提高病毒载体用于人类基因治疗应用的安全性。
