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固有免疫：AIM2炎性小体对细胞质DNA的感知

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

作者信息

Schroder Kate, Muruve Daniel A, Tschopp Jürg

机构信息

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

出版信息

Curr Biol. 2009 Mar 24;19(6):R262-5. doi: 10.1016/j.cub.2009.02.011.

DOI:10.1016/j.cub.2009.02.011

PMID:19321146

Abstract

Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death.

摘要

细胞质中的双链DNA可触发巨噬细胞死亡并分泌促炎细胞因子白细胞介素-1β（IL-1β）。最近的报道阐述了这一现象背后的机制。在检测到DNA后，HIN-200家族成员AIM2触发炎性小体的组装，最终导致半胱天冬酶-1激活、IL-1β成熟和细胞焦亡。