长期 HBV 联合治疗下是否会出现临床 HBV 耐药？一项挑战性病例报告。
Is there Emergence of Clinical HBV Resistance Under Long-Term HBV Combination Therapy? A Challenging Case Report.
机构信息
Infektionsmedizinisches Centrum Hamburg (ICH St. Georg), Germany.
IPM Biotech GmbH, Labor Lademannbogen, Hamburg, Germany.
出版信息
Viruses. 2010 Aug;2(8):1564-1570. doi: 10.3390/v2081564. Epub 2010 Jul 29.
Abstract
A first case of clinical tenofovir (TDF) HBV resistance in an HIV/HBV coinfected patient who developed an acute flare of hepatitis B is reported. The clinical course was accompanied by signs of acute liver failure after being on successful HBV treatment with tenofovir and persistently undetectable HBV-DNA viral load for over five years.
摘要
现报道 1 例 HIV/HBV 合并感染患者发生临床替诺福韦（TDF） HBV 耐药的首例病例，该患者发生乙型肝炎急性发作。在成功接受替诺福韦治疗 HBV 超过五年且 HBV-DNA 病毒载量持续不可检测后，该患者出现急性肝功能衰竭的迹象。
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