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HTLV-1 和 HTLV-2 Tax 蛋白的细胞内定位和细胞因子相互作用：相似性和功能差异。

Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences.

机构信息

Department of Life and Reproduction Sciences, University of Verona, Strada le Grazie 8, 37134, Verona, Italy.

Centre for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland.

出版信息

Viruses. 2011 May;3(5):541-560. doi: 10.3390/v3050541. Epub 2011 May 9.

DOI:10.3390/v3050541
PMID:21994745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3185761/
Abstract

Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 and Tax-2 differ in their cellular localization and in their interaction pattern with cellular factors? In this review, we summarize Tax-1 and Tax-2 structural and phenotypic properties, their interaction with factors involved in signal transduction and their localization-related behavior within the cell. Special attention will be given to the distinctions between Tax-1 and Tax-2 that likely play an important role in their transactivation activity.

摘要

人类 T 淋巴细胞白血病病毒 1 型（HTLV-1）和 2 型（HTLV-2）具有非常相似的基因组结构，但 HTLV-1 的致病性强于 HTLV-2。这种差异是由于它们的反式激活 Tax 蛋白 Tax-1 和 Tax-2 引起的吗？Tax-1 和 Tax-2 在细胞定位和与细胞因子相互作用模式上是否存在差异？在这篇综述中，我们总结了 Tax-1 和 Tax-2 的结构和表型特性、它们与信号转导中涉及的因子的相互作用以及它们在细胞内的定位相关行为。我们将特别关注 Tax-1 和 Tax-2 之间的差异，这些差异可能在它们的反式激活活性中发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfb0/3185761/327ec03bddd6/viruses-03-00541f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfb0/3185761/960ebf8753ee/viruses-03-00541f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfb0/3185761/178f64da8cda/viruses-03-00541f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfb0/3185761/45372a004da6/viruses-03-00541f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfb0/3185761/c8a845f2ca22/viruses-03-00541f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfb0/3185761/327ec03bddd6/viruses-03-00541f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfb0/3185761/960ebf8753ee/viruses-03-00541f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfb0/3185761/178f64da8cda/viruses-03-00541f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfb0/3185761/45372a004da6/viruses-03-00541f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfb0/3185761/c8a845f2ca22/viruses-03-00541f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfb0/3185761/327ec03bddd6/viruses-03-00541f5.jpg

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