抗病毒治疗在乙肝相关肝细胞癌中的作用
The Role of Antiviral Therapy for HBV-Related Hepatocellular Carcinoma.
作者信息
Yu Liang-He, Li Nan, Cheng Shu-Qun
机构信息
Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200438, China.
出版信息
Int J Hepatol. 2011;2011:416459. doi: 10.4061/2011/416459. Epub 2011 May 30.
Abstract
Hepatocellular carcinoma (HCC) is a highly prevalent and lethal cancer worldwide; despite the curative treatment for HCC, the rate of tumor recurrence after hepatectomy remains high. Tumor recurrence can occur early (<2 years) or late (>2 years) as metastases or de novo tumors. Several tumor factors were associated with HCC recurrence; high hepatitis B virus (HBV) load is the major risk factor for late recurrence of HCC after resection. Preoperative antiviral therapy improves liver function, and postoperative reduce HCC recurrence. In this paper, we focus on antiviral treatment to improve the liver function, prevent recurrence, and lengthen the overall survival for HBV-related HCC.
摘要
肝细胞癌（HCC）是全球一种高度流行且致命的癌症；尽管对HCC有治愈性治疗方法，但肝切除术后肿瘤复发率仍然很高。肿瘤复发可早期（<2年）或晚期（>2年）发生，表现为转移或新发肿瘤。几种肿瘤因素与HCC复发相关；高乙肝病毒（HBV）载量是HCC切除术后晚期复发的主要危险因素。术前抗病毒治疗可改善肝功能，并在术后降低HCC复发率。在本文中，我们重点关注抗病毒治疗以改善肝功能、预防复发并延长HBV相关HCC患者的总生存期。
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