Am J Cancer Res. 2011;1(5):629-49. Epub 2011 Apr 26.
Tight regulation of both the NF-κB pathway and the autophagy process is necessary for maintenance of cellular homeostasis. Deregulation of both pathways is frequently observed in cancer cells and is associated with tumorigenesis and tumor cell resistance to cancer therapies. Autophagy is involved in several cellular functions regulated by NF-κB including cell survival, differentiation, senescence, inflammation, and immunity. On a molecular level, autophagy and NF-κB share common upstream signals and regulators and can control each other through positive or negative feedback loops, thus ensuring homeostatic responses. Here, we summarize and discuss the most recent discoveries that shed new light on the complex interplay between autophagy and NF-κB signaling pathways; this certainly has functional relevance in tumorigenesis and tumor responses to therapy.
NF-κB 通路和自噬过程的紧密调节对于维持细胞内稳态是必要的。两条通路的失调在癌细胞中经常观察到，与肿瘤发生和肿瘤细胞对癌症治疗的耐药性有关。自噬参与 NF-κB 调节的几种细胞功能，包括细胞存活、分化、衰老、炎症和免疫。在分子水平上，自噬和 NF-κB 共享共同的上游信号和调节剂，并且可以通过正反馈或负反馈环相互控制，从而确保内稳态反应。在这里，我们总结和讨论了最近的发现，这些发现为自噬和 NF-κB 信号通路之间的复杂相互作用提供了新的认识；这在肿瘤发生和肿瘤对治疗的反应中具有功能相关性。
