Kondi-Pafiti A, Kleanthis K C, Mavrigiannaki P, Iavazzo C, Bakalianou K, Hassiakos D, Liapis A
Pathology Laboratory, "Aretaieion" University of Athens, Greece.
Clin Exp Obstet Gynecol. 2011;38(3):214-6.
24 cases of single umbilical artery (SUA) are presented and the related histopathological findings of the fetuses and placentas examined. SUA is the most common congenital anomaly of the umbilical cord, resulting in the absence of one of the two umbilical arteries. It has an incidence of approximately 2.1% in autopsy material and there is evidence that is associated with anomalies of the fetus and placenta.
MATERIAL-METHOD: The files were reviewed of 24 cases with SUA, out of 1,570 autopsies of fetuses and placentas performed in the Pathology Laboratory of Aretaieion Hospital, due to spontaneous or induced abortions after written parental consent.
The incidence of SUA was 1.6%. Gestational age ranged between the 15th and 33rd week and mother's age ranged from 17-44 years. Three of 24 cases were twin pregnancies; 17/24 fetuses were male. In 21/24 cases complex congenital anomalies were observed and in five of 24 cases chromosomal anomalies were detected. In eight of 24 placentas extensive infarcts were observed; 7/24 dysmaturity, 5/24 severe chorioamnionitis, 3/24 extensive fibrin accumulation and 1/24 chorioangiosis.
SUA is an umbilical congenital anomaly associated with severe fetal congenital anomalies and once detected with ultrasound techniques, further and more detailed control of the fetus is considered mandatory.
报告24例单脐动脉（SUA）病例，并对所检查胎儿及胎盘的相关组织病理学发现进行阐述。单脐动脉是最常见的脐带先天性异常，表现为两条脐动脉中的一条缺失。在尸检材料中的发生率约为2.1%，且有证据表明其与胎儿及胎盘异常有关。
回顾了阿雷泰厄翁医院病理实验室对1570例胎儿及胎盘进行尸检的档案，这些尸检是在获得父母书面同意后，针对自然流产或人工流产的情况进行的，其中有24例为单脐动脉病例。
单脐动脉的发生率为1.6%。孕周在第15至33周之间，母亲年龄在17至44岁之间。24例中有3例为双胎妊娠；24例中有17例胎儿为男性。24例中有21例观察到复杂的先天性异常，24例中有5例检测到染色体异常。24例中有8例胎盘观察到广泛梗死；24例中有7例发育不成熟，24例中有5例严重绒毛膜羊膜炎，24例中有3例广泛纤维蛋白沉积，24例中有1例绒毛血管病。
单脐动脉是一种与严重胎儿先天性异常相关的脐带先天性异常，一旦通过超声技术检测到，对胎儿进行进一步更详细的检查被认为是必要的。
