• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

先天性皮肤发育不全及孕期暴露于甲巯咪唑相关的其他异常情况。

Aplasia cutis congenita and other anomalies associated with methimazole exposure during pregnancy.

作者信息

Rodríguez-García Cristina, González-Hernández Sorahaya, Hernández-Martín Angela, Pérez-Robayna Nuria, Sánchez Rosalba, Torrelo Antonio

机构信息

Department of Dermatology, Hospital Universitario de Canarias, University of La Laguna (Canary Islands), Spain.

Department of Dermatology, Hospital del Niño Jesús, Madrid, Spain.

出版信息

Pediatr Dermatol. 2011 Nov-Dec;28(6):743-745. doi: 10.1111/j.1525-1470.2011.01572.x. Epub 2011 Oct 13.

DOI:10.1111/j.1525-1470.2011.01572.x
PMID:21995270
Abstract

Aplasia cutis congenita (ACC) is a congenital defect consisting of a circumscribed absence of skin that usually involves the scalp. The etiology is uncertain, and several teratogenic agents such as methimazole have been involved. We report two cases of ACC and other anomalies in newborns exposed to methimazole during pregnancy.

摘要

先天性皮肤发育不全（ACC）是一种先天性缺陷，表现为局限性皮肤缺失，通常累及头皮。其病因尚不确定，已有多种致畸剂如甲巯咪唑与之相关。我们报告了两例孕期暴露于甲巯咪唑的新生儿发生ACC及其他异常的病例。

相似文献

1
Aplasia cutis congenita and other anomalies associated with methimazole exposure during pregnancy.先天性皮肤发育不全及孕期暴露于甲巯咪唑相关的其他异常情况。
Pediatr Dermatol. 2011 Nov-Dec;28(6):743-745. doi: 10.1111/j.1525-1470.2011.01572.x. Epub 2011 Oct 13.
2
Aplasia cutis congenita after exposure to methimazole: a causal relationship?
Br J Dermatol. 1995 Dec;133(6):994-6. doi: 10.1111/j.1365-2133.1995.tb06940.x.
3
Aplasia cutis congenita after methimazole exposure in utero successfully treated with basic fibroblast growth factor.孕期暴露于甲巯咪唑后发生的先天性皮肤发育不全，经碱性成纤维细胞生长因子成功治疗。
Int J Dermatol. 2010 Mar;49(3):334-5. doi: 10.1111/j.1365-4632.2009.04254.x.
4
Aplasia cutis congenita following in utero methimazole exposure.宫内暴露于甲巯咪唑后发生的先天性皮肤发育不全。
J Pediatr Endocrinol Metab. 2007 May;20(5):585-6. doi: 10.1515/jpem.2007.20.5.585.
5
[Aplasia cutis congenita and antithyroid drugs during pregnancy: Case series and literature review].
Ann Dermatol Venereol. 2016 Jun-Jul;143(6-7):423-35. doi: 10.1016/j.annder.2016.02.018. Epub 2016 Mar 28.
6
Aplasia cutis congenita after methimazole exposure in utero.
Pediatr Dermatol. 2004 Jul-Aug;21(4):491-4. doi: 10.1111/j.0736-8046.2004.21417.x.
7
Aplasia cutis congenita with skull defect in a monozygotic twin after exposure to methimazole in utero.宫内暴露于甲巯咪唑后单卵双胎之一出现先天性皮肤发育不全伴颅骨缺损。
Birth Defects Res A Clin Mol Teratol. 2007 Oct;79(10):680-4. doi: 10.1002/bdra.20395.
8
Aplasia cutis congenita due to methimazol exposure within the first trimester of pregnancy: case report.孕期头三个月接触甲巯咪唑导致的先天性皮肤发育不全：病例报告
J Perinat Med. 2011 Nov;39(6):743-4. doi: 10.1515/jpm.2011.089. Epub 2011 Aug 2.
9
Treatment of graves' disease with antithyroid drugs in the first trimester of pregnancy and the prevalence of congenital malformation.抗甲状腺药物治疗 Graves 病与妊娠早期先天畸形的患病率。
J Clin Endocrinol Metab. 2012 Jul;97(7):2396-403. doi: 10.1210/jc.2011-2860. Epub 2012 Apr 30.
10
Carbimazole embryopathy: implications for the choice of antithyroid drugs in pregnancy.卡比马唑胚胎病：对妊娠期抗甲状腺药物选择的影响。
QJM. 2012 Feb;105(2):189-93. doi: 10.1093/qjmed/hcq248. Epub 2011 Jan 21.

引用本文的文献

1
A Case Series of Aplasia Cutis Congenita and Its Management.先天性皮肤发育不全病例系列及其处理
Cureus. 2025 Mar 6;17(3):e80135. doi: 10.7759/cureus.80135. eCollection 2025 Mar.
2
Scientific Opinion on the public health hazards to be covered by inspection of meat from sheep and goats.关于绵羊和山羊肉类检验所涵盖的公共卫生危害的科学意见。
EFSA J. 2013 Jun 27;11(6):3265. doi: 10.2903/j.efsa.2013.3265. eCollection 2013 Jun.
3
Treatment of Graves' hyperthyroidism with thionamides: a position paper on indications and safety in pregnancy.
硫脲类药物治疗格雷夫斯甲亢：妊娠适应证和安全性的立场文件。
J Endocrinol Invest. 2020 Feb;43(2):257-265. doi: 10.1007/s40618-019-01148-w. Epub 2019 Nov 29.
4
Aplasia cutis congenita: Two case reports and discussion of the literature.先天性皮肤发育不全：两例病例报告及文献讨论
Surg Neurol Int. 2017 Nov 9;8:273. doi: 10.4103/sni.sni_188_17. eCollection 2017.
5
Congenital anomalies in children exposed to antithyroid drugs in-utero: a meta-analysis of cohort studies.子宫内接触抗甲状腺药物的儿童先天性异常：队列研究的荟萃分析。
PLoS One. 2015 May 14;10(5):e0126610. doi: 10.1371/journal.pone.0126610. eCollection 2015.
6
Pregnancy outcome in women treated with methimazole or propylthiouracil during pregnancy.孕期接受甲巯咪唑或丙硫氧嘧啶治疗的女性的妊娠结局。
J Endocrinol Invest. 2015 Sep;38(9):977-85. doi: 10.1007/s40618-015-0281-z. Epub 2015 Apr 4.
7
Conservative Healing of an 11 × 9-cm Aplasia Cutis Congenita of the Scalp with Bone Defect.头皮11×9厘米先天性皮肤发育不全伴骨缺损的保守性愈合
J Neurol Surg Rep. 2014 Dec;75(2):e220-3. doi: 10.1055/s-0034-1387195. Epub 2014 Aug 11.
8
Coexistence of aplasia cutis congenita, faun tail nevus and fetus papyraceus.先天性皮肤发育不全、兽尾痣和纸样胎儿并存。
J Dermatol Case Rep. 2013 Sep 30;7(3):93-6. doi: 10.3315/jdcr.2013.1148. eCollection 2013.