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携带 mda-7/IL-24 的条件复制型腺病毒用于癌症治疗。

Conditionally replicating adenoviruses carrying mda-7/IL-24 for cancer therapy.

机构信息

Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, China.

出版信息

Acta Oncol. 2012 Mar;51(3):285-92. doi: 10.3109/0284186X.2011.621447. Epub 2011 Oct 13.

DOI:10.3109/0284186X.2011.621447
PMID:21995527
Abstract

BACKGROUND

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) suppresses growth and induces apoptosis in a broad range of human cancers without significant cytotoxicity to normal cells. Conditionally replicating adenoviruses (CRAds) not only have the ability to destroy cancer cells but may also be potential vectors for the expression of therapeutic genes.

METHODS

This review provides an overview of specifications for a novel anti-tumor approach CRAds carrying IL-24, and discusses recent progress in this field.

RESULTS

Studies in multiple laboratories report that CRAds carrying IL-24 selectively induced apoptosis in some cancer cells, and enhanced selective toxicity to cancer cells when combined with chemotherapeutic agents.

CONCLUSION

CRAds carrying IL-24 may prove a novel and effective approach for the treatment of cancers.

摘要

背景

黑色素瘤分化相关基因 7/白细胞介素 24（mda-7/IL-24）在广泛的人类癌症中抑制生长并诱导细胞凋亡，而对正常细胞没有明显的细胞毒性。条件复制腺病毒（CRAds）不仅具有破坏癌细胞的能力，而且还可能是治疗基因表达的潜在载体。

方法

本综述概述了携带白细胞介素 24 的新型抗肿瘤方法 CRAds 的特点，并讨论了该领域的最新进展。

结果

多个实验室的研究报告称，携带白细胞介素 24 的 CRAds 选择性地诱导一些癌细胞凋亡，并与化疗药物联合使用时增强了对癌细胞的选择性毒性。

结论

携带白细胞介素 24 的 CRAds 可能成为治疗癌症的一种新的有效方法。

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Conditionally replicating adenoviruses carrying mda-7/IL-24 for cancer therapy.携带 mda-7/IL-24 的条件复制型腺病毒用于癌症治疗。
Acta Oncol. 2012 Mar;51(3):285-92. doi: 10.3109/0284186X.2011.621447. Epub 2011 Oct 13.
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Is mda-7/IL-24 a "magic bullet" for cancer?黑色素瘤分化相关基因7/白细胞介素-24是治疗癌症的“神奇子弹”吗？
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Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.黑色素瘤分化相关基因-7，即mda-7/IL-24，以不依赖p53的方式选择性地诱导恶性胶质瘤的生长抑制、凋亡和放射增敏作用。
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