Laboratory of Lymphocyte Function, Department of Biochemistry & Cancer Biology, School of Medicine, Meharry Medical College, 2005 Harold D West Basic Sciences Building, 1005 Dr DB Todd Jr Boulevard, Nashville, TN 37208, USA.
Immunotherapy. 2011 Oct;3(10):1143-66. doi: 10.2217/imt.11.102.
Increased evidence of cross-talk between NK cells and other immune cells has enhanced the possibilities of exploiting the interplay between the activation and inhibition of NK cells for immunotherapeutic purposes. The battery of receptors possessed by NK cells help them to efficiently detect aberrant and infected cells and embark on the signaling pathways necessary to eliminate them. Endogenous expansion of NK cells and their effector mechanisms are under exploration for enhancing adoptive immunotherapy prospects in combination with immunostimulatory and cell-death-sensitizing treatments against cancer, viral infections and other pathophysiological autoimmune conditions. Various modes of NK cell manipulation are being undertaken to overcome issues such as relapse and graft rejections associated with adoptive immunotherapy. While tracing the remarkable properties of NK cells and the major developments in this field, we highlight the role of immune cooperativity in the betterment of current immunotherapeutic approaches.
越来越多的证据表明 NK 细胞与其他免疫细胞之间存在串扰，这增强了利用 NK 细胞的激活和抑制之间的相互作用来进行免疫治疗的可能性。NK 细胞所拥有的一系列受体有助于它们有效地检测异常和感染的细胞，并启动消除这些细胞所需的信号通路。正在探索内源性 NK 细胞的扩增及其效应机制，以结合免疫刺激和细胞死亡敏感治疗，增强过继免疫疗法在癌症、病毒感染和其他病理生理自身免疫疾病方面的前景。正在采取各种 NK 细胞操作模式来克服与过继免疫疗法相关的复发和移植物排斥等问题。在追踪 NK 细胞的显著特性和该领域的主要进展的同时，我们强调了免疫协同作用在改善当前免疫治疗方法中的作用。
