Watzl Carsten, Long Eric O
Institute for Immunology, University Heidelberg, Heidelberg, Germany.
Curr Protoc Immunol. 2010 Aug;Chapter 11:Unit 11.9B. doi: 10.1002/0471142735.im1109bs90.
Natural killer (NK) cells are important for early immune responses to viral infections and cancer. Upon activation, NK cells secrete cytokines and chemokines, and kill sensitive target cells by releasing the content of cytolytic granules. This unit is focused on the signal transduction pathways that regulate NK cell activities in response to contact with other cells. We will highlight signals regulating NK cell adhesion to target cells and describe the induction of cellular cytotoxicity by the engagement of different NK cell activation receptors. Negative signaling induced by inhibitory receptors opposes NK cell activation and provides an important safeguard from NK cell reactivity toward normal, healthy cells. We will discuss the complex integration of the different signals that occur during interaction of NK cells with target cells.
自然杀伤（NK）细胞对于病毒感染和癌症的早期免疫反应至关重要。激活后，NK细胞分泌细胞因子和趋化因子，并通过释放溶细胞颗粒的内容物来杀死敏感靶细胞。本单元聚焦于调节NK细胞与其他细胞接触时活性的信号转导途径。我们将着重介绍调节NK细胞与靶细胞黏附的信号，并描述不同NK细胞激活受体的结合所诱导的细胞毒性。抑制性受体诱导的负向信号传导对抗NK细胞激活，并为防止NK细胞对正常健康细胞产生反应性提供重要保障。我们将讨论NK细胞与靶细胞相互作用过程中发生的不同信号的复杂整合。
